Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity
	Liang, Shaojun 2; Zhou, Hui 2; Yin, Nuoya 2; Lu, Yuanping 2; Faiola, Francesco 2
刊名	JOURNAL OF HAZARDOUS MATERIALS
	2019-08-15
卷号	376 页码:223-232
关键词	Mouse embryonic stem cells (mESCs) Tetrabromobisphenol A (TBBPA) Embryoid bodies (EBs) Developmental toxicity
ISSN号	0304-3894
英文摘要	The frequent detection of tetrabromobisphenol A (TBBPA) in the human body, especially in umbilical cord serum and breast milk, has raised concerns about TBBPA potential effects on embryonic development. The differentiation of embryonic stem cells (ESCs) in vitro can serve as a model for the early stages of embryonic development. In this study, we differentiated mouse ESCs via 3D aggregates called embryoid bodies in presence of environment and human relevant TBPPA concentrations for 28 days. We collected samples at different time points and analyzed TBBPA-dependent global gene expression changes by RNA-seq. Our analyses revealed a potential TBBPA multifaceted developmental toxicity with effects on the nervous and cardiac/skeletal muscle systems. Mechanistically, our findings suggest TBBPA endocrine disrupting activities in part via prolactin naling.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42535]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 2.Chinese Acad Sci, State Key Lab Environm Chem & Ecotoxicol, Res Ctr Ecoenvironm Sci, Beijing 100085, Peoples R China
推荐引用方式 GB/T 7714	Liang, Shaojun,Zhou, Hui,Yin, Nuoya,et al. Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity[J]. JOURNAL OF HAZARDOUS MATERIALS,2019,376:223-232.
APA	Liang, Shaojun,Zhou, Hui,Yin, Nuoya,Lu, Yuanping,&Faiola, Francesco.(2019).Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity.JOURNAL OF HAZARDOUS MATERIALS,376,223-232.
MLA	Liang, Shaojun,et al."Embryoid body-based RNA-seq analyses reveal a potential TBBPA multifaceted developmental toxicity".JOURNAL OF HAZARDOUS MATERIALS 376(2019):223-232.