Diagnostic significance of metallothionein members in recognizing cadmium exposure in various organs under low-dose exposure

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Diagnostic significance of metallothionein members in recognizing cadmium exposure in various organs under low-dose exposure
	Shen, Xinming 2; Liu, Wei 2; Chen, Yongjiu 2; Guo, Yifan ; Gao, Ming 2; Chen, Weiping 1,2; Liu, Yajun 3; Liu, Sijin 2
刊名	CHEMOSPHERE
	2019-08-01
卷号	229 页码:32-40
关键词	Cadmium pollution Metallothionein Correlation Family members Surrogate Diagnosis
ISSN号	0045-6535
英文摘要	Metallothioneins (MTs) are known to protect cells against oxidative stress, especially providing protection against cadmium (Cd) toxicity. To date, besides liver and kidney, the expression profiles of MT members have not been thoroughly determined in a full-spectrum of organs, especially under low-dose exposure settings. Furthermore, their diagnostic value has not been evaluated in reflecting the Cd exposure in diverse organs. In the present study, we unearthed the expression profiles of five MT members in diverse organs from mice upon low-dose Cd exposure. Compared to most organs, the deposition of Cd in cartilage has been overlooked in the past, implying the potential Cd toxicity to the joint. In contrast to MT1 and MT2 (MT1/2), the expression levels of MT3, MTL5 and MT4 were minimal with or without Cd treatment. Distinct from Cd mass, the levels of MT1/2 were similar in heart and lung to that of kidney. Our study signified the rationale of MT1/2 induction in recognizing Cd exposure extent in diverse organs including liver, kidney, heart and lung. Importantly, MT1/2 expression was induced in liver and lung cells even upon low-dose Cd exposure. Thus, our combined data unraveled the expression of MT members across various organs in Cd-exposed mice, and pinpointed their diagnostic value in characterizing Cd poisoning. (C) 2019 Elsevier Ltd. All rights reserved.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42527]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Univ Chinese Acad Sci, Beijing, Peoples R China 2.Chinese Acad Sci Beijing, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Urban & Reg Ecol, Beijing 100085, Peoples R China 4.Peking Univ, Hlth Sci Ctr, Beijing Jishuitan Hosp, Beijing 100035, Peoples R China
推荐引用方式 GB/T 7714	Shen, Xinming,Liu, Wei,Chen, Yongjiu,et al. Diagnostic significance of metallothionein members in recognizing cadmium exposure in various organs under low-dose exposure[J]. CHEMOSPHERE,2019,229:32-40.
APA	Shen, Xinming.,Liu, Wei.,Chen, Yongjiu.,Guo, Yifan.,Gao, Ming.,...&Liu, Sijin.(2019).Diagnostic significance of metallothionein members in recognizing cadmium exposure in various organs under low-dose exposure.CHEMOSPHERE,229,32-40.
MLA	Shen, Xinming,et al."Diagnostic significance of metallothionein members in recognizing cadmium exposure in various organs under low-dose exposure".CHEMOSPHERE 229(2019):32-40.