Capture and elimination of Staphylococcus aureus based on Langmuir-Blodgett MnO2 nanowire monolayer promotes infected wound healing | |
Chen, Bolei2; Ji, Fang3; Wang, Chang1; Gao, Yue1; Zhou, Zhen4; Li, Zhi5; Cao, Huiming1; Hao, Liteng1; Liu, Guangliang1; Liu, Jingfu2 | |
刊名 | JOURNAL OF MATERIALS CHEMISTRY B |
2019-07-14 | |
卷号 | 7期号:26页码:4198-4206 |
ISSN号 | 2050-750X |
英文摘要 | Infections caused by Staphylococcus aureus (S. aureus) have a significant contribution to delayed wound healing, and thus raise a particular public health concern. Controlling the interaction between bacterial and tissue cells is considered as a key factor to affect the critical colonization and spreading invasive infection. Thus, we designed and fabricated a manganese dioxide nanowire monolayer based on the Langmuir-Blodgett method. The nanowire monolayer was functionalized by and transferred onto the surface of a tetrabromobisphenol A (TBBPA)-embedded polydimethylsiloxane (PDMS) membrane. The as-prepared composite membrane could decrease the bacterial invasion by capturing and killing the bacteria on its surface. An average capture efficiency of 90% was observed. 87% of the captured bacteria were killed according to the extended release of TBBPA from the PDMS membrane. The results from in vivo experiments demonstrate that the as-prepared antibacterial membrane could promote the infected wound healing in a mouse model. This IgG-functionalized MnO2 nanowire-coated TBBPA-embedded PDMS membrane appears promising in potential clinical applications against external infections caused by S. aureus. |
内容类型 | 期刊论文 |
源URL | [http://ir.rcees.ac.cn/handle/311016/42518] |
专题 | 生态环境研究中心_环境化学与生态毒理学国家重点实验室 |
作者单位 | 1.Jianghan Univ, Sch Med, Wuhan 430056, Hubei, Peoples R China 2.Jianghan Univ, Inst Interdisciplinary Res, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Hubei, Peoples R China 3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, POB 2871, Beijing 100085, Peoples R China 4.Jianghan Univ, Inst Environm & Hlth, Hubei Key Lab Environm & Hlth Effects Persistent, Wuhan 430056, Hubei, Peoples R China 5.Jianghan Univ, Sch Chem & Environm Engn, Minist Educ, Key Lab Optoelect Chem Mat & Devices, Wuhan 430056, Hubei, Peoples R China 6.Gen Hosp Chinese PLA Cent Theater Command, Dept Orthopedis, Wuhan 430070, Hubei, Peoples R China |
推荐引用方式 GB/T 7714 | Chen, Bolei,Ji, Fang,Wang, Chang,et al. Capture and elimination of Staphylococcus aureus based on Langmuir-Blodgett MnO2 nanowire monolayer promotes infected wound healing[J]. JOURNAL OF MATERIALS CHEMISTRY B,2019,7(26):4198-4206. |
APA | Chen, Bolei.,Ji, Fang.,Wang, Chang.,Gao, Yue.,Zhou, Zhen.,...&Liang, Yong.(2019).Capture and elimination of Staphylococcus aureus based on Langmuir-Blodgett MnO2 nanowire monolayer promotes infected wound healing.JOURNAL OF MATERIALS CHEMISTRY B,7(26),4198-4206. |
MLA | Chen, Bolei,et al."Capture and elimination of Staphylococcus aureus based on Langmuir-Blodgett MnO2 nanowire monolayer promotes infected wound healing".JOURNAL OF MATERIALS CHEMISTRY B 7.26(2019):4198-4206. |
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