Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo

CORC > 生态环境研究中心 > 中国科学院生态环境研究中心 > 环境化学与生态毒理学国家重点实验室

	Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo
	Yang, Xiaoxi 1; Ku, Tingting 2; Sun, Zhendong 1; Liu, Qian S.; Yin, Nuoya ; Zhou, Qunfang 1,3; Faiola, Francesco 1; Liao, Chunyang ; Jiang, Guibin 1
刊名	TOXICOLOGY LETTERS
	2019-09-15
卷号	312 页码:139-147
关键词	TCDD Teratoma formation Mouse embryonic stem cells Teratocarcinoma Carcinogenic effects
ISSN号	0378-4274
英文摘要	As the most toxic dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has gained lots of concerns, due to its diverse deleterious effects. However, the knowledge on carcinogenic risk of TCDD during early stage of development remains scarce. The in vivo teratoma formation model based on the transplantation of embryonic stem cells (ESCs) in immunodeficient mice is appealing for studying pluripotency and tumorigenicity in developmental biology, and also shows promise in environmental toxicology, especially in carcinogenesis researches. In this study, the malignant transformation of mouse embryonic stem cells (mESCs) pretreated with TCDD was investigated during their in vivo differentiation using teratoma formation model. Based on characterization of the pluripotency and differentiation capabilities of mESCs, evil changes in teratomas derived from TCDD-exposed mESCs were systematically studied. The results showed that TCDD significantly up-regulated CYP1A1 transcriptional levels in mESCs, elevated the incidence of malignant change in mESC-derived teratomas, and caused indefinite proliferation capabilities in sequential cultures of tumor tissues. The findings suggested that TCDD could exert carcinogenic effect on mESCs during their differentiation into teratoma in vivo, and more attention should be paid to the adverse health effects of this chemical during gestation or early developmental period.
内容类型	期刊论文
源URL	[http://ir.rcees.ac.cn/handle/311016/42510]
专题	生态环境研究中心_环境化学与生态毒理学国家重点实验室
作者单位	1.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Chem & Ecotoxicol, Beijing 100085, Peoples R China 2.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China 3.Shanxi Univ, Res Ctr Environm & Hlth, Coll Environm & Resource, Taiyuan 030006, Shanxi, Peoples R China 4.Jianghan Univ, Inst Environm & Hlth, Wuhan 430056, Hubei, Peoples R China
推荐引用方式 GB/T 7714	Yang, Xiaoxi,Ku, Tingting,Sun, Zhendong,et al. Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo[J]. TOXICOLOGY LETTERS,2019,312:139-147.
APA	Yang, Xiaoxi.,Ku, Tingting.,Sun, Zhendong.,Liu, Qian S..,Yin, Nuoya.,...&Jiang, Guibin.(2019).Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo.TOXICOLOGY LETTERS,312,139-147.
MLA	Yang, Xiaoxi,et al."Assessment of the carcinogenic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin using mouse embryonic stem cells to form teratoma in vivo".TOXICOLOGY LETTERS 312(2019):139-147.