Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain | |
Hua, Jiaojiao1,4; Yang, Zhengyi4; Jiang, Tianzi1,3,4; Yu, Shan2,3,4 | |
刊名 | Science Bulletin |
2021 | |
期号 | 无页码:无 |
关键词 | Gene-gene interaction Co-expression Structural networkFunctional network Functional network Higher-order interactions |
ISSN号 | 2095-9273 |
DOI | https://doi.org/10.1016/j.scib.2021.01.003 |
英文摘要 | The orchestrated expression of thousands of genes gives rise to the complexity of the human brain. However, the structures governing these myriad gene-gene interactions remain unclear. By analyzing transcription data from more than 2000 sites in six human brains, we found that pairwise interactions between genes, without considering any higher-order interactions, are sufficient to predict the transcriptional pattern of the genome for individual brain regions and the transcriptional profile of the entire brain consisting of more than 200 areas. These findings suggest a quadratic complexity of transcriptional patterns in the human brain, which is much simpler than expected. In addition, using a pairwise interaction model, we revealed that the strength of gene-gene interactions in the human brain gives rise to the nearly maximal number of transcriptional clusters, which may account for the functional and structural richness of the brain. |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/44805] |
专题 | 自动化研究所_脑网络组研究中心 |
通讯作者 | Yu, Shan |
作者单位 | 1.School of Artificial Intelligence, University of Chinese Academy of Sciences 2.School of Future Technology, University of Chinese Academy of Sciences 3.CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences 4.Brainnetome Center and National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences |
推荐引用方式 GB/T 7714 | Hua, Jiaojiao,Yang, Zhengyi,Jiang, Tianzi,et al. Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain[J]. Science Bulletin,2021(无):无. |
APA | Hua, Jiaojiao,Yang, Zhengyi,Jiang, Tianzi,&Yu, Shan.(2021).Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain.Science Bulletin(无),无. |
MLA | Hua, Jiaojiao,et al."Pairwise interactions in gene expression determine a hierarchical transcriptional profile in the human brain".Science Bulletin .无(2021):无. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论