A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation

doi:10.1155/2020/8750167

	A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation
	Li, Licong 3,4; Zhou, Jin 1; Sun, Hongji 2; Liu, Jing 4; Wang, Hongrui 4; Liu, Xiuling 4; Wang, Changyong 1
刊名	COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE
	2020-09-15
卷号	2020 页码:13
ISSN号	1748-670X
DOI	10.1155/2020/8750167
通讯作者	Liu, Xiuling(liuxiuling121@hotmail.com) ; Wang, Changyong(wcy2000_zm@163.com)
英文摘要	Gamma-aminobutyric acid (GABA) is critical for proper neural network function and can activate astrocytes to induce neuronal excitability; however, the mechanism by which astrocytes transform inhibitory signaling to excitatory enhancement remains unclear. Computational modeling can be a powerful tool to provide further understanding of how GABA-activated astrocytes modulate neuronal excitation. In the present study, we implemented a biophysical neuronal network model to investigate the effects of astrocytes on excitatory pre- and postsynaptic terminals following exposure to increasing concentrations of external GABA. The model completely describes the effects of GABA on astrocytes and excitatory presynaptic terminals within the framework of glutamatergic gliotransmission according to neurophysiological findings. Utilizing this model, our results show that astrocytes can rapidly respond to incoming GABA by inducing Ca(2+)oscillations and subsequent gliotransmitter glutamate release. Elevation in GABA concentrations not only naturally decreases neuronal spikes but also enhances astrocytic glutamate release, which leads to an increase in astrocyte-mediated presynaptic release and postsynaptic slow inward currents. Neuronal excitation induced by GABA-activated astrocytes partly counteracts the inhibitory effect of GABA. Overall, the model helps to increase knowledge regarding the involvement of astrocytes in neuronal regulation using simulated bath perfusion of GABA, which may be useful for exploring the effects of GABA-type antiepileptic drugs.
资助项目	National Natural Science Foundation of China[61703133] ; National Natural Science Foundation of China[61673158] ; Hebei Province Nature Science Fund for Young Scholars[F2018201070]
WOS关键词	GLUTAMATE RELEASE ; CA2+ OSCILLATIONS ; GLIOTRANSMISSION ; INHIBITION ; DEPOLARIZATION ; CONDUCTANCES ; MECHANISMS ; SYNCHRONY ; AGONISTS ; GLIA
WOS研究方向	Mathematical & Computational Biology
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000576096800001
资助机构	National Natural Science Foundation of China ; Hebei Province Nature Science Fund for Young Scholars
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/42071]
专题	自动化研究所_脑网络组研究中心
通讯作者	Liu, Xiuling; Wang, Changyong
作者单位	1.Acad Mil Med Sci, Inst Mil Cognit & Brain Sci, Dept Neural Engn & Biol Interdisciplinary Studies, Beijing 100850, Peoples R China 2.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing 100190, Peoples R China 3.Hebei Univ, Coll Phys Sci & Technol, Baoding 071002, Peoples R China 4.Hebei Univ, Key Lab Digital Med Engn Hebei Prov, Baoding 071002, Peoples R China
推荐引用方式 GB/T 7714	Li, Licong,Zhou, Jin,Sun, Hongji,et al. A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation[J]. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,2020,2020:13.
APA	Li, Licong.,Zhou, Jin.,Sun, Hongji.,Liu, Jing.,Wang, Hongrui.,...&Wang, Changyong.(2020).A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation.COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE,2020,13.
MLA	Li, Licong,et al."A Computational Model to Investigate GABA-Activated Astrocyte Modulation of Neuronal Excitation".COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE 2020(2020):13.