Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population

doi:10.3389/fpsyt.2020.00446

	Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population
	Yang, Yongfeng 2,3,7; Zhang, Luwen 2,3,7; Guo, Dong 2,3,7; Zhang, Lin 1; Yu, Hongyan 3; Liu, Qing 2,3,7; Su, Xi 2,3,7; Shao, Minglong 2,3,7; Song, Men 2,3,7; Zhang, Yan 2,3,7
刊名	FRONTIERS IN PSYCHIATRY
	2020-05-25
卷号	11 页码:9
关键词	schizophrenia DTNBP1 polymorphism psychotic symptoms cognition
ISSN号	1664-0640
DOI	10.3389/fpsyt.2020.00446
通讯作者	Yang, Ge(yangge19800804@163.com) ; Lv, Luxian(lvx928@126.com)
英文摘要	Objectives Schizophrenia (SZ) is a complex psychiatric disorder that has a strong genetic basis. Dystrobrevin-binding protein 1 (DTNBP1) is one of the genes thought to be pivotal in regulating the glutamatergic system. Studies have suggested that variations inDTNBP1confer susceptibility to SZ and clinical symptoms. Here, we performed a two-stage independent verification study to identify polymorphisms of theDTNBP1gene that might be associated with SZ in the Han Chinese population. Methods In stage 1, 14 single nucleotide polymorphisms (SNPs) were genotyped in 528 paranoid SZ patients and 528 healthy controls (HCs) using the Illumina GoldenGate assays on a BeadStation 500G Genotyping System. In stage 2, ten SNPs were genotyped in an independent sample of 1,031 SZ patients and 621 HCs using the Illumina 660k Genotyping System. Clinical symptoms were assessed using the Positive and Negative Syndrome Scale. Results There was a significant association related to allele frequency, and a trend association in relation to genotype between SZ patients and HCs at rs4712253 (p= 0.03 and 0.05, respectively). These associations were not evident following Bonferroni correction (p >0.05 for both). Haplotype association analysis revealed that only two haplotypes (GAG and GAA; rs16876575-rs9464793-rs4712253) were significantly different between SZ patients and HCs (chi(2)= 4.24, 6.37,p= 0.04 and 0.01, respectively). In addition, in SZ patients there was a significant association in the rs4964793 genotype for positive symptoms, and in the rs1011313 genotype for excitement/hostility symptoms (p= 0.01 and 0.002, respectively). We found a significant association in the baseline symbol digital modalities test (SDMT), forward-digital span (DS), backward-DS, and semantic fluency between SZ patients and HCs (p <0.05 for all). Finally, the SNP rs1011313 genotypes were associated with SDMT in SZ patients (p= 0.04). Conclusion This study provides further evidence that SNP rs4712253 ofDTNBP1has a nominal association with SZ in the Han Chinese population. Such a genotype variation may play a role in psychopathology and cognitive function.
资助项目	National Natural Science Foundation of China[81671330] ; National Natural Science Foundation of China[81971252] ; High Scientific and Technological Research Fund of Xinxiang Medical University[2017ZDCG-04] ; National Key Research and Development Program of China[2016YFC1307001] ; Medical science and technology research project of Henan Province[2018020373] ; Science and Technology Project of Henan Province[192102310086] ; fund of Henan Clinical Research Center for Mental Disorders ; support project for the Disciplinary group of Psychology and Neuroscience, Xinxiang Medical University
WOS关键词	GENE DTNBP1 ; DYSBINDIN ; LOCUS ; HAPLOTYPE ; VARIANTS ; BRAIN ; RISK
WOS研究方向	Psychiatry
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000543203500001
资助机构	National Natural Science Foundation of China ; High Scientific and Technological Research Fund of Xinxiang Medical University ; National Key Research and Development Program of China ; Medical science and technology research project of Henan Province ; Science and Technology Project of Henan Province ; fund of Henan Clinical Research Center for Mental Disorders ; support project for the Disciplinary group of Psychology and Neuroscience, Xinxiang Medical University
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/39936]
专题	自动化研究所_脑网络组研究中心
通讯作者	Yang, Ge; Lv, Luxian
作者单位	1.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Tongji Med Coll, Wuhan, Peoples R China 2.Xinxiang Med Univ, Henan Key Lab Biol Psychiat, Xinxiang, Henan, Peoples R China 3.Xinxiang Med Univ, Henan Mental Hosp, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China 4.Henan Prov Peoples Hosp, Psychiat Dept, Zhengzhou, Peoples R China 5.UMass Mem Med Ctr, Worcester, MA USA 6.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 7.Huazhong Univ Sci & Technol, Affiliated Wuhan Mental Hlth Ctr, Psychiat Dept, Tongji Med Coll, Wuhan, Peoples R China 8.Univ Massachusetts, Med Sch, Psychiat Dept, Worcester, MA 01605 USA 9.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China 10.Peking Univ, Inst Mental Hlth, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Yang, Yongfeng,Zhang, Luwen,Guo, Dong,et al. Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population[J]. FRONTIERS IN PSYCHIATRY,2020,11:9.
APA	Yang, Yongfeng.,Zhang, Luwen.,Guo, Dong.,Zhang, Lin.,Yu, Hongyan.,...&Lv, Luxian.(2020).Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population.FRONTIERS IN PSYCHIATRY,11,9.
MLA	Yang, Yongfeng,et al."Association ofDTNBP1With Schizophrenia: Findings From Two Independent Samples of Han Chinese Population".FRONTIERS IN PSYCHIATRY 11(2020):9.