Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy

doi:10.3389/fpsyt.2020.00236

	Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy
	Tao, Qi 2,3,6,7; Yang, Yongfeng 1,4,11,13; Yu, Hongyan 1; Fan, Lingzhong 5,8,9; Luan, Shuxin 10,12; Zhang, Lei 10,12; Zhao, Hua 10; Lv, Luxian 1,11,13; Jiang, Tianzi 4,5,8,9; Song, Xueqin 2,6,7
刊名	FRONTIERS IN PSYCHIATRY
	2020-04-03
卷号	11 页码:8
关键词	treatment-resistant depression (TRD) transcranial magnetic stimulation (TMS) anatomical connectivity subgenual anterior cingulated cortex (sACC) prefrontal cortex (PFC)
ISSN号	1664-0640
DOI	10.3389/fpsyt.2020.00236
通讯作者	Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Song, Xueqin(fccsongxq@zzu.edu.cn)
英文摘要	Objectives Abnormal activity of the subgenual anterior cingulate cortex (sACC) is implicated in depression, suggesting the sACC as a potentially effective target for therapeutic modulation in cases resistant to conventional treatments (treatment-resistant depression, TRD). We hypothesized that areas in the prefrontal cortex (PFC) with direct fiber connections to the sACC may be particularly effective sites for treatment using transcranial magnetic stimulation (TMS). The aim of this study was to identify PFC sites most strongly connected to the sACC. Methods Two neuroimaging data sets were used to construct anatomic and functional connectivity maps using sACC as the seed region. Data set 1 included magnetic resonance (MR) images from 20 healthy controls and Data set 2 included MR images from 15 TRD patients and 15 additional healthy controls. PFC voxels with maximum values in the mean anatomic connection probability maps were identified as optimal sites for TMS. Results Both right and left PFC contained sites strongly connected to the sACC, but the coordinates (in Montreal Neurological Institute space) of peak anatomic connectivity differed slightly between hemispheres. The left PFC site connected directly to the sACC both anatomically and functionally, while the right PFC site was functionally connected to the posterior cingulate cortex (PCC). Conclusions Both left and right PFC are functionally connected to regions implicated in depression, the sACC and PCC, respectively. These bilateral PFC sites may be effective TMS targets to treat TRD.
资助项目	National Natural Science Foundation of China[81671330] ; National Natural Science Foundation of China[81571318] ; Medical Science and Technology Research Project of Henan Province[2018020373] ; Health and Family Planning Commission of Henan Province[201501015] ; Department of Science and Technology of Henan Province[162102410061] ; Department of Science and Technology of Henan Province[2017JQ023] ; School and Hospital Co-incubation Funds[2017-BSTDJJ-04] ; Research Council of Norway[223273]
WOS关键词	DORSOLATERAL PREFRONTAL CORTEX ; DEEP BRAIN-STIMULATION ; TREATMENT-RESISTANT DEPRESSION ; SUBCALLOSAL CINGULATE GYRUS ; CEREBRAL-BLOOD-FLOW ; MAJOR DEPRESSION ; FUNCTIONAL CONNECTIVITY ; EFFICACY ; MOOD ; RTMS
WOS研究方向	Psychiatry
语种	英语
出版者	FRONTIERS MEDIA SA
WOS记录号	WOS:000528705700001
资助机构	National Natural Science Foundation of China ; Medical Science and Technology Research Project of Henan Province ; Health and Family Planning Commission of Henan Province ; Department of Science and Technology of Henan Province ; School and Hospital Co-incubation Funds ; Research Council of Norway
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/39371]
专题	自动化研究所_脑网络组研究中心
通讯作者	Jiang, Tianzi; Song, Xueqin
作者单位	1.Xinxiang Med Univ, Henan Mental Hosp, Dept Psychiat, Affiliated Hosp 2, Xinxiang, Henan, Peoples R China 2.Zhengzhou Univ, Henan Psychiat Transformat Res Key Lab, Zhengzhou, Peoples R China 3.Zhengzhou Univ, Acad Med Sci, Zhengzhou, Peoples R China 4.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China 5.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 6.Zhengzhou Univ, Dept Psychiat, Affiliated Hosp 1, Zhengzhou, Peoples R China 7.Zhengzhou Univ, Biol Psychiat Int Joint Lab Henan, Zhengzhou, Peoples R China 8.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 9.Univ Chinese Acad Sci, Beijing, Peoples R China 10.Jilin Univ, Coll Basic Med Sci, Dept Physiol, Jilin, Jilin, Peoples R China
推荐引用方式 GB/T 7714	Tao, Qi,Yang, Yongfeng,Yu, Hongyan,et al. Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy[J]. FRONTIERS IN PSYCHIATRY,2020,11:8.
APA	Tao, Qi.,Yang, Yongfeng.,Yu, Hongyan.,Fan, Lingzhong.,Luan, Shuxin.,...&Song, Xueqin.(2020).Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy.FRONTIERS IN PSYCHIATRY,11,8.
MLA	Tao, Qi,et al."Anatomical Connectivity-Based Strategy for Targeting Transcranial Magnetic Stimulation as Antidepressant Therapy".FRONTIERS IN PSYCHIATRY 11(2020):8.