Impact of AVM location on language cortex right-hemisphere reorganization: A voxel-based lesion-symptom mapping study

doi:10.1016/j.clineuro.2019.105628

	Impact of AVM location on language cortex right-hemisphere reorganization: A voxel-based lesion-symptom mapping study
	Deng, Xiaofeng 4; Wei, Xuehu 1,2; Zhang, Yan 4; Wang, Bo 3; Zhang, Dong 4; Yu, Shaochen 4; Jiang, Tianzi 1,2; Zhao, Jizong 4
刊名	CLINICAL NEUROLOGY AND NEUROSURGERY
	2020-02-01
卷号	189 页码:6
关键词	Cerebral arteriovenous malformation Language cortex reorganization Stroke Functional magnetic resonance imaging VLSM
ISSN号	0303-8467
DOI	10.1016/j.clineuro.2019.105628
通讯作者	Jiang, Tianzi(jiangtz@nlpr.ia.ac.cn) ; Zhao, Jizong(zhaojz205@163.com)
英文摘要	Objectives: Cerebral arteriovenous malformations (AVMs) are congenital malformations, and right-sided dominance of the language cortex is not a rare phenomenon for patients with AVM involving language area. We tried to use voxel-based lesion-symptom mapping (VLSM) method to depict the location of AVM nidus and to demonstrate the relationship between AVM location and the pattern of language cortex reorganization. Patients and methods: The authors retrospectively reviewed clinical and imaging data of 70 adult patients with unruptured cerebral AVMs who underwent blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) of language task. All patients were right handed, and all lesions were located in the left cerebral hemisphere. Lateralization indexes (LI) of the BOLD signals were calculated for Broca and Wernicke areas separately and were used to reflect the degree of right-sided dominance of the two language areas. VLSM method was applied to study the relationship between AVM location and LI of language task activations. Results: Statistical analysis revealed that the change of LI of Broca area was significantly associated with lesions located in the inferior frontal gyrus, pre- and post-central gyrus, supramarginal gyrus and middle frontal gyrus. The change of LI of Wernicke area was significantly associated with lesions located in the left superior, middle, inferior and transverse temporal gyrus. Conclusion: These findings provide new evidence that the language cortex reorganization patterns in AVM patients have anatomic specificity.
资助项目	Chinese National Natural Science Foundation[81701088] ; Beijing talents project[2017000021469G211] ; capital health research and development of special[2016-2-2043]
WOS关键词	TRANSCRANIAL MAGNETIC STIMULATION ; BRAIN ARTERIOVENOUS-MALFORMATIONS ; DOMINANCE ; LATERALIZATION ; SPEECH ; GLIOMAS
WOS研究方向	Neurosciences & Neurology ; Surgery
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000515210000016
资助机构	Chinese National Natural Science Foundation ; Beijing talents project ; capital health research and development of special
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/38448]
专题	自动化研究所_脑网络组研究中心
通讯作者	Jiang, Tianzi; Zhao, Jizong
作者单位	1.Chinese Acad Sci, Brainnetome Ctr, Inst Automat, Beijing, Peoples R China 2.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Key Lab NeuroInformat, Minist Educ, Chengdu, Peoples R China 3.Chinese Acad Sci, Beijing MRI Ctr Brain Res, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing, Peoples R China 4.Capital Med Univ, Beijing Tiantan Hosp, China Natl Clin Res Ctr Neurol Dis, Dept Neurosurg, Beijing, Peoples R China
推荐引用方式 GB/T 7714	Deng, Xiaofeng,Wei, Xuehu,Zhang, Yan,et al. Impact of AVM location on language cortex right-hemisphere reorganization: A voxel-based lesion-symptom mapping study[J]. CLINICAL NEUROLOGY AND NEUROSURGERY,2020,189:6.
APA	Deng, Xiaofeng.,Wei, Xuehu.,Zhang, Yan.,Wang, Bo.,Zhang, Dong.,...&Zhao, Jizong.(2020).Impact of AVM location on language cortex right-hemisphere reorganization: A voxel-based lesion-symptom mapping study.CLINICAL NEUROLOGY AND NEUROSURGERY,189,6.
MLA	Deng, Xiaofeng,et al."Impact of AVM location on language cortex right-hemisphere reorganization: A voxel-based lesion-symptom mapping study".CLINICAL NEUROLOGY AND NEUROSURGERY 189(2020):6.