Electroconvulsive therapy treatment responsive multimodal brain networks | |
Qi, Shile9; Abbott, Christopher C.8; Narr, Katherine L.7; Jiang, Rongtao4,5,6; Upston, Joel8; McClintock, Shawn M.3; Espinoza, Randall7; Jones, Tom8; Zhi, Dongmei4,5,6; Sun, Hailun4,5,6 | |
刊名 | HUMAN BRAIN MAPPING |
2020-01-06 | |
卷号 | 41期号:7页码:11 |
关键词 | depressive episodes electroconvulsive therapy multimodal fusion treatment response |
ISSN号 | 1065-9471 |
DOI | 10.1002/hbm.24910 |
英文摘要 | Electroconvulsive therapy is regarded as the most effective antidepressant treatment for severe and treatment-resistant depressive episodes. Despite the efficacy of electroconvulsive therapy, the neurobiological underpinnings and mechanisms underlying electroconvulsive therapy induced antidepressant effects remain unclear. The objective of this investigation was to identify electroconvulsive therapy treatment responsive multimodal biomarkers with the 17-item Hamilton Depression Rating Scale guided brain structure-function fusion in 118 patients with depressive episodes and 60 healthy controls. Results show that reduced fractional amplitude of low frequency fluctuations in the prefrontal cortex, insula and hippocampus, linked with increased gray matter volume in anterior cingulate, medial temporal cortex, insula, thalamus, caudate and hippocampus represent electroconvulsive therapy responsive covarying functional and structural brain networks. In addition, relative to nonresponders, responder-specific electroconvulsive therapy related brain networks occur in frontal-limbic network and are associated with successful therapeutic outcomes. Finally, electroconvulsive therapy responsive brain networks were unrelated to verbal declarative memory. Using a data-driven, supervised-learning method, we demonstrated that electroconvulsive therapy produces a remodeling of brain functional and structural covariance that was unique to antidepressant symptom response, but not linked to memory impairment. |
资助项目 | China Natural Science Foundation[61773380] ; National Science Foundation[1539067] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDBS03040100] ; National Institute of Health[P20GM103472] ; Beijing Municipal Science and Technology Commission[Z181100001518005] ; National Institute of Health[1R56MH117107] ; National Institute of Health[1R01EB005846] ; National Institute of Health[1R01MH094524] ; National Institute of Health[P30GM122734] ; National Institute of Health[R01EB020407] ; National Institute of Mental Health[U01MH111826] |
WOS关键词 | MAJOR DEPRESSION ; SUBSEQUENT ; ECT ; PHARMACOTHERAPY ; CONSORTIUM ; PREDICTION ; REMISSION ; DIAGNOSIS ; RBANS |
WOS研究方向 | Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000505639000001 |
内容类型 | 期刊论文 |
源URL | [http://ir.ia.ac.cn/handle/173211/29471] |
专题 | 自动化研究所_脑网络组研究中心 |
通讯作者 | Abbott, Christopher C.; Sui, Jing |
作者单位 | 1.Sichuan Univ, West China Hosp, Huaxi Brain Res Ctr, Chengdu, Sichuan, Peoples R China 2.Chinese Acad Sci, Ctr Excellence Brain Sci, Inst Automat, Beijing, Peoples R China 3.Univ Texas Southwestern Med Ctr Dallas, Dept Psychiat, Dallas, TX 75390 USA 4.Univ Chinese Acad Sci, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, Beijing, Peoples R China 6.Chinese Acad Sci, Inst Automat, Brainnetome Ctr, Beijing, Peoples R China 7.Univ Calif Los Angeles, Dept Neurol Psychiat & Biobehav Sci, Los Angeles, CA 90024 USA 8.Univ New Mexico, Dept Psychiat, Albuquerque, NM 87131 USA 9.Emory Univ, Georgia State Univ, Georgia Inst Technol, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30322 USA |
推荐引用方式 GB/T 7714 | Qi, Shile,Abbott, Christopher C.,Narr, Katherine L.,et al. Electroconvulsive therapy treatment responsive multimodal brain networks[J]. HUMAN BRAIN MAPPING,2020,41(7):11. |
APA | Qi, Shile.,Abbott, Christopher C..,Narr, Katherine L..,Jiang, Rongtao.,Upston, Joel.,...&Calhoun, Vince D..(2020).Electroconvulsive therapy treatment responsive multimodal brain networks.HUMAN BRAIN MAPPING,41(7),11. |
MLA | Qi, Shile,et al."Electroconvulsive therapy treatment responsive multimodal brain networks".HUMAN BRAIN MAPPING 41.7(2020):11. |
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