Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography

doi:10.1364/AO.398967

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography
	Zhang, Peng 3,4; Liu, Jie 4; Hui, Hui 2,3,5; An, Yu 1; Wang, Kun 2,3,5; Yang, Xin 2,3,5; Tian, Jie 2,3,5
刊名	APPLIED OPTICS
	2020-09-10
卷号	59 期号:26 页码:7961-7967
ISSN号	1559-128X
DOI	10.1364/AO.398967
通讯作者	Liu, Jie()
英文摘要	Direct reconstruction of the noncontact time-domain fluorescence molecular lifetime tomography (TD-FMLT) with current nonlinear algorithms has suffered from complexity and heavy computation loads of the physical model for a large imaging area in TD-FMLT. In this work, we discretize the system matrix along time points and apply a linearized reconstruction algorithm using the fused least absolute shrinkage and selection operator method. The reconstructed yield map and object geometry are used as a priori information to mitigate the ill conditions. This approach is implemented on a fully noncontact TD-FMLT system equipped with a femtosecond pulse laser and a high-speed, time-gated camera. We validate the methodology using both numerical simulations and inhomogeneous phantom experiments. The results exhibit good localization accuracy for fluorescent targets and an efficient computation capability for the reconstruction of fluorescence lifetime in noncontact TD-FMLT. We envision that the proposed linear scheme for the direct reconstruction method in noncontact TD-FMLT has a significant potential for in vivo preclinical studies. (C) 2020 Optical Society of America
资助项目	National Key Research and Development Program of China[2017YFA0700401] ; National Key Research and Development Program of China[2016YFC0103803] ; National Key Research and Development Program of China[2017YFA0205200] ; National Natural Science Foundation of China[81671851] ; National Natural Science Foundation of China[81827808] ; National Natural Science Foundation of China[81527805] ; National Natural Science Foundation of China[81571836] ; National Natural Science Foundation of China[81227901] ; Strategic Priority Research Program of Chinese Academy of Sciences[XDB32030200] ; Scientific Instrument R&D Program of Chinese Academy of Sciences[YJKYYQ20170075] ; Youth Innovation Promotion Association of the ChineseAcademy of Sciences[2018167]
WOS关键词	SYSTEM
WOS研究方向	Optics
语种	英语
出版者	OPTICAL SOC AMER
WOS记录号	WOS:000571484700029
资助机构	National Key Research and Development Program of China ; National Natural Science Foundation of China ; Strategic Priority Research Program of Chinese Academy of Sciences ; Scientific Instrument R&D Program of Chinese Academy of Sciences ; Youth Innovation Promotion Association of the ChineseAcademy of Sciences
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/42013]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Liu, Jie
作者单位	1.Beihang Univ, Beijing Adv Innovat Ctr Big Data Based Precis Med, Sch Med, Beijing 100083, Peoples R China 2.Inst Automat, Beijing Key Lab Mol Imaging, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Inst Automat, CAS Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Beijing Jiaotong Univ, Sch Comp & Informat Technol, Dept Biomed Engn, Beijing 100044, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100190, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Peng,Liu, Jie,Hui, Hui,et al. Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography[J]. APPLIED OPTICS,2020,59(26):7961-7967.
APA	Zhang, Peng.,Liu, Jie.,Hui, Hui.,An, Yu.,Wang, Kun.,...&Tian, Jie.(2020).Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography.APPLIED OPTICS,59(26),7961-7967.
MLA	Zhang, Peng,et al."Linear scheme for the direct reconstruction of noncontact time-domain fluorescence molecular lifetime tomography".APPLIED OPTICS 59.26(2020):7961-7967.