Simple structural indocyanine green-loaded microbubbles for dual-modality imaging and multi-synergistic photothermal therapy in prostate cancer

doi:10.1016/j.nano.2020.102229

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Simple structural indocyanine green-loaded microbubbles for dual-modality imaging and multi-synergistic photothermal therapy in prostate cancer
	Yin, Tinghui 4; Wang, Kun 3; Qiu, Chen 4; Zhang, Xinling 4; Zhou, Huichao 4; You, Yujia 4; Ren, Jie 4; Mao, Ren 2; Yang, Biying 1; Miao, Xiaoyan 4
刊名	NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
	2020-08-01
卷号	28 页码:11
关键词	Indocyanine green Microbubbles Molecular ultrasound imaging Photoacoustic imaging Photothermal therapy
ISSN号	1549-9634
DOI	10.1016/j.nano.2020.102229
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Zheng, Rongqin(zhengrq@mail.sysu.edu.cn)
英文摘要	As problems with the overuse of radical prostate cancer (PCa) treatment are increasingly exposed, focal therapy represents the direction of low- or intermediate-risk PCa management in the future. However, inaccurate diagnosis and low controllability of focal therapy hinder its clinical translation. In this study, we develop simple structural cyclic arginine-glycine-aspartic (cRGD) peptide-modified and indocyanine green (ICG)-loaded microbubbles (cRGD-ICG-MBs) for ultrasound-photoacoustic imaging and multi-synergistic photothermal therapy (PTT) to address the above problems. Precise PCa diagnosis is achieved by molecular ultrasound imaging. cRGD-targeting and low-frequency ultrasound with an amplitude of 500 kPa convert MBs into nanoparticles for enhanced ICG delivery. A low frequency 2500 kPa amplitude ultrasound enables temporary vasculature destruction, which minimizes heat loss during PTT. Specifically, ICG in the tumor region is 14-fold higher than the control, resulting in satisfactory PTT. Our study highlights that this theranostic strategy possesses considerable clinical translational potential, especially in mini-invasive and individualized PCa therapy. (C) 2020 Elsevier Inc. All rights reserved.
WOS关键词	FOCAL THERAPY ; NANOPARTICLES
WOS研究方向	Science & Technology - Other Topics ; Research & Experimental Medicine
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000563777100013
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/40530]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Zheng, Rongqin
作者单位	1.Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangdong Prov Hosp Chinese Med, Dept Neurol, Guangzhou, Peoples R China 2.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou, Peoples R China 3.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 4.Sun Yat Sen Univ, Affiliated Hosp 3, Lab Novel Optoacoust Ultrason Imaging, Dept Med Ultrason, Guangzhou, Peoples R China
推荐引用方式 GB/T 7714	Yin, Tinghui,Wang, Kun,Qiu, Chen,et al. Simple structural indocyanine green-loaded microbubbles for dual-modality imaging and multi-synergistic photothermal therapy in prostate cancer[J]. NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,2020,28:11.
APA	Yin, Tinghui.,Wang, Kun.,Qiu, Chen.,Zhang, Xinling.,Zhou, Huichao.,...&Zheng, Rongqin.(2020).Simple structural indocyanine green-loaded microbubbles for dual-modality imaging and multi-synergistic photothermal therapy in prostate cancer.NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE,28,11.
MLA	Yin, Tinghui,et al."Simple structural indocyanine green-loaded microbubbles for dual-modality imaging and multi-synergistic photothermal therapy in prostate cancer".NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE 28(2020):11.