Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma

doi:10.2217/nnm-2018-0424

CORC > 自动化研究所 > 中国科学院自动化研究所 > 中国科学院分子影像重点实验室

	Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma
	Zhou, Qunfang 1,4; Wang, Kun 1; Dou, Jianping 4; Cao, Feng 3; Liu, Fengyong 2; Yuan, Hongjun 2; Mu, Mengjuan 4; Xu, Jinshun 4; Zhang, Dongyun 4; Li, Xin 4
刊名	NANOMEDICINE
	2019-08-01
卷号	14 期号:16 页码:2151-2167
关键词	hepatocellular carcinoma liposomes microwave ablation optoacoustic tomography imaging theranostics
ISSN号	1743-5889
DOI	10.2217/nnm-2018-0424
通讯作者	Tian, Jie(jie.tian@ia.ac.cn) ; Yu, Jie(jiemi301@163.com) ; Liang, Ping(liangping301@hotmail.com)
英文摘要	Aim: This study aimed to develop indocyanine green- and doxorubicin-loaded liposomes (DILPs) as theranostic nanoplatform for the detection of hepatocellular carcinoma (HCC) and as an efficient chemotherapeutic to enhance microwave ablation. Materials & methods: DILPs were synthesized and thoroughly characterized. Biocompatibility, tumor uptake and accumulation, and synergistic ablation-chemotherapeutic efficiency were systematically explored in them. In addition, human HCC surgical samples were used to test the affinity of DILPs for HCC. Results: The combination of microwave ablation and DILPs enhanced the ablation efficiency of HCC with apparent tumor inhibition. DILPs exhibited excellent diagnostic ability and could detect 2.5-mm HCC lesions via optoacoustic tomography imaging. DILPs had better affinity for human HCC surgical samples compared with normal liver tissue. Conclusion: Theranostic DILPs could serve as promising nanoparticles for treatment and management of HCC in the clinic.
资助项目	National Natural Science Foundation of China[81622024] ; National Key R&D Program of China[2017YFC0112000] ; Postdoctoral Science Foundation of China[2017M613327]
WOS关键词	RADIOFREQUENCY ABLATION ; TUMOR ; NANOPARTICLES ; DOXORUBICIN ; CANCER ; MULTICENTER ; SURVIVAL ; RECURRENCE ; EFFICACY ; THERAPY
WOS研究方向	Biotechnology & Applied Microbiology ; Science & Technology - Other Topics
语种	英语
出版者	FUTURE MEDICINE LTD
WOS记录号	WOS:000498812800004
资助机构	National Natural Science Foundation of China ; National Key R&D Program of China ; Postdoctoral Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.ia.ac.cn/handle/173211/29397]
专题	自动化研究所_中国科学院分子影像重点实验室
通讯作者	Tian, Jie; Yu, Jie; Liang, Ping
作者单位	1.Chinese Acad Sci, Inst Automat, Key Lab Mol Imaging, Beijing 100190, Peoples R China 2.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Radiol, Beijing 100853, Peoples R China 3.Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing 100853, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Qunfang,Wang, Kun,Dou, Jianping,et al. Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma[J]. NANOMEDICINE,2019,14(16):2151-2167.
APA	Zhou, Qunfang.,Wang, Kun.,Dou, Jianping.,Cao, Feng.,Liu, Fengyong.,...&Liang, Ping.(2019).Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma.NANOMEDICINE,14(16),2151-2167.
MLA	Zhou, Qunfang,et al."Theranostic liposomes as nanodelivered chemotherapeutics enhanced the microwave ablation of hepatocellular carcinoma".NANOMEDICINE 14.16(2019):2151-2167.