Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications

doi:10.1016/j.carbpol.2020.116002

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications
	Qin, Yukun 1,2; Li, Pengcheng 1,2; Guo, Zhanyong 3
刊名	CARBOHYDRATE POLYMERS
	2020-05-15
卷号	236 页码:17
关键词	Cationic chitosan derivatives Antifungals Structural optimization strategy Antifungal therapy
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2020.116002
通讯作者	Li, Pengcheng(pcli@qdio.ac.cn) ; Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	The increasing resistance of pathogen fungi poses a global public concern. There are several limitations in current antifungals, including few available fungicides, severe toxicity of some fungicides, and drug resistance. Therefore, there is an urgent need to develop new antifungals with novel targets. Chitosan has been recognized as a potential antifungal substance due to its good biocompatibility, biodegradability, non-toxicity, and availability in abundance, but its applications are hampered by the low charge density results in low solubility at physiological pH. It is believed that enhancing the positive charge density of chitosan may be the most effective approach to improve both its solubility and antifungal activity. Hence, this review mainly focuses on the structural optimization strategy of cationic chitosan and the potential antifungal applications. This review also assesses and comments on the challenges, shortcomings, and prospect of cationic chitosan derivatives as antifungal therapy.
资助项目	National Key R&D Program of China[2018YFC0311305] ; National Key R&D Program of China[2019YFD0900705] ; Key Research and Development Program of Shandong Province[2018GHY115017] ; Qingdao Applied Basic Research Project[19-6-2-34-cg] ; Science and technology program of Nantong[MS120170234]
WOS研究方向	Chemistry ; Polymer Science
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000519306900012
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/165870]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Li, Pengcheng; Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Inst Oceanol, Ctr Ocean Mega Sci, Key Lab Expt Marine Biol, Qingdao, Peoples R China 2.Pilot Natl Lab Marine Sci & Technol Qingdao, Lab Marine Drugs & Bioprod, 1 Wenhai Rd, Qingdao 266237, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Qin, Yukun,Li, Pengcheng,Guo, Zhanyong. Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications[J]. CARBOHYDRATE POLYMERS,2020,236:17.
APA	Qin, Yukun,Li, Pengcheng,&Guo, Zhanyong.(2020).Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications.CARBOHYDRATE POLYMERS,236,17.
MLA	Qin, Yukun,et al."Cationic chitosan derivatives as potential antifungals: A review of structural optimization and applications".CARBOHYDRATE POLYMERS 236(2020):17.