Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance

doi:10.1007/s00253-019-10219-0

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance
	Xu, Gangming; Yang, Suiqun
刊名	APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
	2019-12-01
卷号	103 期号:23-24 页码:9373-9378
关键词	Microbial hormone gamma-butyrolactone Quorum sensing Antibiotic resistance
ISSN号	0175-7598
DOI	10.1007/s00253-019-10219-0
英文摘要	Bacteria modulate their physiological behavior by responding to various signal molecules. The signals are received by cognate receptors, which usually mediate transcriptional regulation. Streptomyces employ gamma-butyrolactones (GBLs) and cognate GBL receptors (GblRs) to regulate secondary metabolism and morphological development. However, there are additional transcriptional regulators called pseudo GblR regulators, which cannot bind GBLs and are not directly associated with GBL synthase. The pseudo GblR regulators may act as transcriptional repressors and respond to antibiotic signals. They play regulatory roles in coordination of antibiotic biosynthesis by connecting the hormone feed-forward loops and the antibiotic feedback loops. As the TetR family members, they might also have evolutionary roles between the transcriptional regulators of quorum sensing and antibiotic resistance. Understanding the regulatory and evolutionary roles of the pseudo GblR family would be helpful for fine-tuning regulation of antibiotic biosynthesis and resistance.
资助项目	National Natural Science Foundation of China[31570038] ; National Natural Science Foundation of China[31200042]
WOS研究方向	Biotechnology & Applied Microbiology
语种	英语
出版者	SPRINGER
WOS记录号	WOS:000509524600014
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/164421]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Xu, Gangming
作者单位	Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China
推荐引用方式 GB/T 7714	Xu, Gangming,Yang, Suiqun. Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2019,103(23-24):9373-9378.
APA	Xu, Gangming,&Yang, Suiqun.(2019).Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,103(23-24),9373-9378.
MLA	Xu, Gangming,et al."Regulatory and evolutionary roles of pseudo gamma-butyrolactone receptors in antibiotic biosynthesis and resistance".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 103.23-24(2019):9373-9378.