Highly oxygenated polyketides produced by Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the fresh roots of the medicinal plant Artemisia argyi

doi:10.1016/j.bioorg.2019.103448

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	Highly oxygenated polyketides produced by Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the fresh roots of the medicinal plant Artemisia argyi
	Shi, Xiao-Shan 1,2,3,4; Li, Hong-Lei 1,2,4,5; Li, Xiao-Ming 1,2,4,5; Wang, Dun-Jia 3; Li, Xin 1,2,4,5; Meng, Ling-Hong 1,2,4,5; Zhou, Xing-Wang 3; Wang, Bin-Gui 1,2,4,5
刊名	BIOORGANIC CHEMISTRY
	2020
卷号	94 页码:9
关键词	Artemisia argyi Endophytic fungus Trichoderma koningiopsis Secondary metabolites Polyketides Antimicrobial activities
ISSN号	0045-2068
DOI	10.1016/j.bioorg.2019.103448
通讯作者	Zhou, Xing-Wang(zhouxw@hbnu.edu.cn) ; Wang, Bin-Gui(wangbg@ms.qdio.ac.cn)
英文摘要	Eight new highly oxygenated fungal polyketides, namely, 15-hydroxy-1,4,5,6-tetra-epi-koninginin G (1), 14-hydroxykoninginin E (2), koninginin U (3), 4'-hydroxykoninginin U (4), koninginin V (5), 14-ketokoninginin B (6), 14-hydroxykoninginin B (7), and 7-O-methylkoninginin B (8), together with six known related analogues (9-14), were isolated from Trichoderma koningiopsis QA-3, a fungus obtained from the inner root tissue of the well known medicinal plant Artemisia argyi. All these compounds are bicyclic polyketides, with compound 1 contains unusual hemiketal moiety at C-5 and compounds 2-14 having ketone group at C-1 and double bond at C-5(6). The structures and absolute configurations of the new compounds were established by spectroscopic analysis, X-ray crystal diffraction, modified Mosher's method, and ECD calculation. The absolute configurations of the known compounds 9, 10, and 12 were determined by X-ray crystal diffractions for the first time. The antimicrobial activities against human pathogen, marine-derived aquatic bacteria, and plant-pathogenic fungi of compounds 1-14 were evaluated, and compound 1 showed remarkable activity against aquatic pathogen Vibrio alginolyticus with MIC value 1 mu g/mL, which is as active as that of the positive control.
资助项目	National Natural Science Foundation of China[31870328] ; Taishan Scholar Program from Shandong Province of China[ts201511060]
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry
语种	英语
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
WOS记录号	WOS:000505596300100
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/164367]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Zhou, Xing-Wang; Wang, Bin-Gui
作者单位	1.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China 3.Hubei Normal Univ, Coll Chem & Chem Engn, Cihu Rd 11, Huangshi 435002, Hubei, Peoples R China 4.Univ Chinese Acad Sci, Yuquan Rd 19A, Beijing 100049, Peoples R China 5.Chinese Acad Sci, Ctr Ocean Megasci, Nanhai Rd 7, Qingdao 266071, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Shi, Xiao-Shan,Li, Hong-Lei,Li, Xiao-Ming,et al. Highly oxygenated polyketides produced by Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the fresh roots of the medicinal plant Artemisia argyi[J]. BIOORGANIC CHEMISTRY,2020,94:9.
APA	Shi, Xiao-Shan.,Li, Hong-Lei.,Li, Xiao-Ming.,Wang, Dun-Jia.,Li, Xin.,...&Wang, Bin-Gui.(2020).Highly oxygenated polyketides produced by Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the fresh roots of the medicinal plant Artemisia argyi.BIOORGANIC CHEMISTRY,94,9.
MLA	Shi, Xiao-Shan,et al."Highly oxygenated polyketides produced by Trichoderma koningiopsis QA-3, an endophytic fungus obtained from the fresh roots of the medicinal plant Artemisia argyi".BIOORGANIC CHEMISTRY 94(2020):9.