Dynamic immune and metabolism response of clam Meretrix petechialis to Vibrio challenge revealed by a time series of transcriptome analysis

doi:10.1016/j.fsi.2019.08.057

CORC > 海洋研究所 > 中国科学院海洋研究所 > 实验海洋生物学重点实验室

	Dynamic immune and metabolism response of clam Meretrix petechialis to Vibrio challenge revealed by a time series of transcriptome analysis
	Yu, Jiajia 1,3; Wang, Hongxia 1,2; Yue, Xin 1,2; Liu, Baozhong 1,2,3
刊名	FISH & SHELLFISH IMMUNOLOGY
	2019-11-01
卷号	94 页码:17-26
关键词	Meretrix petechialis Vibrio DEGs Innate immunity Anabolism
ISSN号	1050-4648
DOI	10.1016/j.fsi.2019.08.057
通讯作者	Liu, Baozhong(bzliu@qdio.ac.cn)
英文摘要	Meretrix petechions is an important commercial aquaculture species in China. During the clam culture period, mass mortality events often occurred due to the Vibrio infection. In this paper, M. petechialis were challenged with Vibrio parahatmolyticus immersion to simulate a natural infection, and the infection process were divided into four phases including latency, prodrome, onset and recovery phases based on the clam mortality data. Then, the dynamic response of clams to Vibrio infection at different infection phases were investigated by transcriptome analysis. A total of 38,067 differentially expressed genes (DEGs) were identified at different infection phases. DEG annotations showed that immune-related and metabolism-related signaling pathways were enriched, indicating that immune defense and metabolism process play key roles during bacterial infection. Three kinds of expression pattern were classified by cluster analysis, including U-shape, L-shape and inverted V-shape. Anabolism and cellular growth proliferation related signaling pathways were repressed (long-lasting or transient) during bacterial infection. However, the immune related signaling pathways with different immune functions showed induction expression or repression expression against bacterial infection, which indicated that immune system take different strategies against bacterial infection. Furthermore, some signaling pathways such as PI3K-Akt signaling pathway both involved in immune defense and cell metabolism. This study provides a sight that the dynamic immunity and metabolic responses may be integrated to improve the host survival and shift more energy for immune defense.
资助项目	National Natural Science Foundation of China[31772845] ; Marine S&T Fund of Shandong Province for Pilot National Laboratory for Marine Science and Technology (Qingdao) ; China Agriculture Research System[CARS-49]
WOS研究方向	Fisheries ; Immunology ; Marine & Freshwater Biology ; Veterinary Sciences
语种	英语
出版者	ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
WOS记录号	WOS:000496892400003
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/163813]
专题	海洋研究所_实验海洋生物学重点实验室
通讯作者	Liu, Baozhong
作者单位	1.Chinese Acad Sci, Ctr Ocean Megasci, Inst Oceanol, CAS Key Lab Expt Marine Biol, Qingdao 266071, Shandong, Peoples R China 2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266000, Shandong, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Yu, Jiajia,Wang, Hongxia,Yue, Xin,et al. Dynamic immune and metabolism response of clam Meretrix petechialis to Vibrio challenge revealed by a time series of transcriptome analysis[J]. FISH & SHELLFISH IMMUNOLOGY,2019,94:17-26.
APA	Yu, Jiajia,Wang, Hongxia,Yue, Xin,&Liu, Baozhong.(2019).Dynamic immune and metabolism response of clam Meretrix petechialis to Vibrio challenge revealed by a time series of transcriptome analysis.FISH & SHELLFISH IMMUNOLOGY,94,17-26.
MLA	Yu, Jiajia,et al."Dynamic immune and metabolism response of clam Meretrix petechialis to Vibrio challenge revealed by a time series of transcriptome analysis".FISH & SHELLFISH IMMUNOLOGY 94(2019):17-26.