Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury

doi:10.1021/acs.jnatprod.1c00027

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	Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury
	Wu, Jianzhang 2; Xi, Yiyuan 2; Li, Ge 2; Zheng, Yuantie 2; Wang, Zhongle 2; Wang, Jingsong 2; Fang, Chengyan 2; Sun, Zhongmin 3; Hu, Linya 2; Jiang, Wei 1
刊名	JOURNAL OF NATURAL PRODUCTS
	2021-04-23
卷号	84 期号:4 页码:1306-1315
ISSN号	0163-3864
DOI	10.1021/acs.jnatprod.1c00027
通讯作者	Zhao, Min(zhaomin@wmu.edu.cn) ; Yan, Pengcheng(yanpc@wmu.edu.cn)
英文摘要	Five new diterpenes, including four new hydroazulenes, (8R,11R)-8, 11- diacetoxypachydictyol A (1), (8R,11R) -6-O-acety1-8- acetoxy-11-hydroxypachydictyol A (2), (8R,11S)-8-acetoxy-11-hydroxypachydictyol A (3), and (8R,11S)-6-O-acety1-8,11-dihydroxypachydictyol A (4), and a secohydroazulene derivative, named 7Z-7,8-seco-7,11-didehydro-8-acetoxypachydictyol A (5), were isolated from a South China Sea collection of a Dictyota sp. nov. brown alga, together with five known analogues (6-10). Structure elucidation was achieved by extensive spectroscopic analysis and comparison with reported data. All compounds showed potent antioxidant effects against H2O2-induced oxidative damage in neuron-like PC12 cells at a low concentration of 2 mu M. The antioxidant property of dictyol C (9) was associated with activation of the Nrf2/ARE signaling pathway; it also showed neuroprotective effects against cerebral ischemia-reperfusion injury (CIRI) in a rat model of transient middle cerebral artery occlusion. As such, hydroazulene diterpenes could serve as lead structures for the development of novel neuroprotective agents against CIRI.
资助项目	Natural Science Foundation of Zhejiang Province, China[LQ19H300003] ; National Natural Science Foundation of China[82073761] ; Outstanding Youth Foundation from Wenzhou Medical University[604091809] ; Opening Project of Zhejiang Provincial Top Key Discipline of Pharmaceutical Sciences[201707]
WOS研究方向	Plant Sciences ; Pharmacology & Pharmacy
语种	英语
出版者	AMER CHEMICAL SOC
WOS记录号	WOS:000644478400038
内容类型	期刊论文
源URL	[http://ir.qdio.ac.cn/handle/337002/170859]
专题	中国科学院海洋研究所
通讯作者	Zhao, Min; Yan, Pengcheng
作者单位	1.Yangzhou Univ, Sch Environm Sci & Engn, Yangzhou 225127, Jiangsu, Peoples R China 2.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Wu, Jianzhang,Xi, Yiyuan,Li, Ge,et al. Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury[J]. JOURNAL OF NATURAL PRODUCTS,2021,84(4):1306-1315.
APA	Wu, Jianzhang.,Xi, Yiyuan.,Li, Ge.,Zheng, Yuantie.,Wang, Zhongle.,...&Yan, Pengcheng.(2021).Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury.JOURNAL OF NATURAL PRODUCTS,84(4),1306-1315.
MLA	Wu, Jianzhang,et al."Hydroazulene Diterpenes from a Dictyota Brown Alga and Their Antioxidant and Neuroprotective Effects Against Cerebral Ischemia-Reperfusion Injury".JOURNAL OF NATURAL PRODUCTS 84.4(2021):1306-1315.