The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis

doi:10.1155/2020/9824615

CORC > 海洋研究所 > 中国科学院海洋研究所

	The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis
	Wang, Yashuo 1; Wang, Wei 3; Wang, Bin 4; Wang, Yunyang 2
刊名	GASTROENTEROLOGY RESEARCH AND PRACTICE
	2020-08-03
卷号	2020 页码:6
ISSN号	1687-6121
DOI	10.1155/2020/9824615
英文摘要	Background. Our aim was to assess the risk of gastrointestinal (GI) hemorrhage associated with diabetes among patients taking low-dose aspirin (<= 325 mg/day). Methods. A systematic search was conducted for publication in English and Chinese using term equivalents for "GI hemorrhage", "aspirin", and "diabetes mellitus" up till April 2020. Electronic databases include PUBMED, EMBASE, Cochrane Library databases, Chinese National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP Database. Two independent authors searched databases and reviewed abstracts for comprehensive studies keeping adequate study quality. Data of weighted odds ratios were statistically evaluated and potential bias was checked. Results. Among 446 publications, eight case-control researches, including 1601 patients, were deemed for this meta-analysis. Patients with diabetes were associated with a higher risk of GI hemorrhage than patients without diabetes: the summary ORs were 3.10 (95% CI, 2.35-4.09). The heterogeneity of the reports was not significant (Chi(2)=3.39, P=0.85; I-2=0%). Conclusion. The meta-analysis showed that aspirin users with diabetes were more likely to have GI hemorrhage. Hence, when treating diabetics with aspirin, the increased risk of GI bleeding should be taken in consideration.
WOS研究方向	Gastroenterology & Hepatology
语种	英语
出版者	HINDAWI LTD
WOS记录号	WOS:000562863300001
内容类型	期刊论文
版本	出版稿
源URL	[http://ir.qdio.ac.cn/handle/337002/168324]
专题	中国科学院海洋研究所
通讯作者	Wang, Yunyang
作者单位	1.Qingdao Univ, Coll Life Sci, Qingdao, Shandong, Peoples R China 2.Qingdao Univ, Dept Endocrinol & Metab, Affiliated Hosp, Qingdao, Shandong, Peoples R China 3.Chinese Acad Sci, Inst Oceanol, Beijing, Peoples R China 4.Qingdao Univ, Dept Med Microbiol, Med Coll, Qingdao, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Wang, Yashuo,Wang, Wei,Wang, Bin,et al. The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis[J]. GASTROENTEROLOGY RESEARCH AND PRACTICE,2020,2020:6.
APA	Wang, Yashuo,Wang, Wei,Wang, Bin,&Wang, Yunyang.(2020).The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis.GASTROENTEROLOGY RESEARCH AND PRACTICE,2020,6.
MLA	Wang, Yashuo,et al."The Risk of Gastrointestinal Hemorrhage in Low-Dose Aspirin Users with Diabetes Mellitus: Systematic Review and Meta-Analysis".GASTROENTEROLOGY RESEARCH AND PRACTICE 2020(2020):6.