Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity

doi:10.1016/j.phytochem.2019.112127

	Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity
	Wang,Zengyuan; Jiang,Mengjun; Khan,Afsar; Cai,Shengbao; Li,Xiaonian; Liu,Junqiu; Kai,Guoyin; Zhao,Tianrui; Cheng,Guiguang; Cao,Jianxin
刊名	PHYTOCHEMISTRY
	2019
卷号	168 页码:UNSP 112127
ISSN号	0031-9422
DOI	10.1016/j.phytochem.2019.112127
英文摘要	Five undescribed C-21 pregnane glycosides, epigycosides D - H, together with four known analogues, two lignans, and a flavonoid have been isolated from the stems of Epigynum cochinchinensis. The structures of pregnane glycosides were elucidated using spectroscopic techniques and acid hydrolysis. The in vitro immunological activities were assessed against Con A-stimulated proliferation of mice splenocytes. The C-21 pregnane glycosides showed immunosuppressive activity in a concentration-dependent manner. Moreover, epigycoside E exhibited a potent immunosuppressive effect, and the IC50 value on Con A-stimulated mice splenocytes was 22.1 +/- 6.4 mu M. Epigycoside E also caused G(0)/G(1) arrest, and inhibited TNF-alpha and IL-2 production.
WOS记录号	WOS:000496894000010
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/71103]
专题	中国科学院昆明植物研究所
推荐引用方式 GB/T 7714	Wang,Zengyuan,Jiang,Mengjun,Khan,Afsar,et al. Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity[J]. PHYTOCHEMISTRY,2019,168:UNSP 112127.
APA	Wang,Zengyuan.,Jiang,Mengjun.,Khan,Afsar.,Cai,Shengbao.,Li,Xiaonian.,...&Cao,Jianxin.(2019).Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity.PHYTOCHEMISTRY,168,UNSP 112127.
MLA	Wang,Zengyuan,et al."Epigynumgenane-type pregnane glycosides from Epigynum cochinchinensis and their immunosuppressive activity".PHYTOCHEMISTRY 168(2019):UNSP 112127.