Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine

doi:10.1021/acs.orglett.9b03319

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine
	Yao, Jian-Neng 1,2; Liang, Xiao 2; Wei, Kun 2; Yang, Yu-Rong 2
刊名	ORGANIC LETTERS
	2019-10-18
卷号	21 期号:20 页码:8485-8487
ISSN号	1523-7060
DOI	10.1021/acs.orglett.9b03319
通讯作者	Yang, Yu-Rong(yangyurong@mail.kib.ac.cn)
英文摘要	A catalytic, enantioselective formal synthesis of monoterpene indole alkaloid (-)-alstoscholarine is described. The synthesis employs an Ir-amine dual catalyzed asymmetric allylation of aldehyde 8 with 3-indolyl vinyl carbinol derivative 7 to furnish chiral aldehyde 6 as a key asymmetric step. Other key reactions include the construction of the 2-ketopyrrole moiety by Nicolaou's method and Tf2O promoted Pictet Spengler cyclization to access Zhu's intermediate 3.
WOS研究方向	Chemistry
语种	英语
WOS记录号	WOS:000492114600070
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70973]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Yang, Yu-Rong
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Yao, Jian-Neng,Liang, Xiao,Wei, Kun,et al. Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine[J]. ORGANIC LETTERS,2019,21(20):8485-8487.
APA	Yao, Jian-Neng,Liang, Xiao,Wei, Kun,&Yang, Yu-Rong.(2019).Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine.ORGANIC LETTERS,21(20),8485-8487.
MLA	Yao, Jian-Neng,et al."Catalytic, Enantioselective Formal Synthesis of Monoterpene Indole Alkaloid (-)-Alstoscholarine".ORGANIC LETTERS 21.20(2019):8485-8487.