Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum

doi:10.1080/10286020.2019.1698551

CORC > 昆明植物研究所 > 中国科学院昆明植物研究所 > 植物化学与西部植物资源持续利用国家重点实验室

	Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum
	Zeng, Yan-Rong 1,4,5; Li, Ya-Na 1,5; Lou, Hua-Yong 1,4,5; Jian, Jun-You 1,5; Gu, Wei 1,5; Huang, Lie-Jun 1,5; Du, Guan-Hua 2; Yuan, Chun-Mao 1,5; Hao, Xiao-Jiang 1,3,4,5
刊名	JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
	2019-12-13
页码	9
关键词	Hypericum monogynum polycyclic polyprenylated acylphloroglucinols (PPAPs) neuroprotective effects structure-activity relationship
ISSN号	1028-6020
DOI	10.1080/10286020.2019.1698551
通讯作者	Du, Guan-Hua(dugh@imm.ac.cn) ; Yuan, Chun-Mao(yuanchunmao01@126.com) ; Hao, Xiao-Jiang(haoxj@mail.kib.ac.cn)
英文摘要	A new polycyclic polyprenylated acylphloroglucinol (PPAP), hypermonin C (1), along with nine known PPAPs (2-10) were obtained from the leaves and twigs of Hypericum monogynum. The structures of the isolates were determined on the basis of extensive spectroscopic analysis. The neuroprotective effects of the isolates against several chemical-induced injuries in SH-SY5Y and PC12 cells were assessed, and most of the compounds exhibited significant protective effects at 10 mu g/ml. Especially, three compounds (1, 3, and 7) showed excellent neuroprotective activity with a cell viability of 92.4% similar to 95.8% in KCl-induced SH-SY5Y cell injury. Their preliminary structure-activity relationship was also discussed and the configuration of substituent in furohyperforin may be critical for the neuroprotective activity of PPAP derivatives.
WOS研究方向	Plant Sciences ; Chemistry ; Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000502731100001
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70604]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	Du, Guan-Hua; Yuan, Chun-Mao; Hao, Xiao-Jiang
作者单位	1.Chinese Acad Sci, Key Lab Chem Nat Prod Guizhou Prov, Guiyang 550014, Guizhou, Peoples R China 2.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab Drug Target Identificat & Drug S, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 4.Guizhou Med Univ, Coll Basic Med, Guiyang 550004, Guizhou, Peoples R China 5.Guizhou Med Univ, State Key Lab Funct & Applicat Med Plants, Guiyang 550014, Guizhou, Peoples R China
推荐引用方式 GB/T 7714	Zeng, Yan-Rong,Li, Ya-Na,Lou, Hua-Yong,et al. Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum[J]. JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,2019:9.
APA	Zeng, Yan-Rong.,Li, Ya-Na.,Lou, Hua-Yong.,Jian, Jun-You.,Gu, Wei.,...&Hao, Xiao-Jiang.(2019).Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum.JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH,9.
MLA	Zeng, Yan-Rong,et al."Polycyclic polyprenylated acylphloroglucinol derivatives with neuroprotective effects from Hypericum monogynum".JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2019):9.