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	Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus
	Liu, Jian-Wen1,2; Huo, Zong-Qing1; Zhao, Qian1; Hao, Xiao-Jiang1; He, Hong-Ping2; Zhang, Yu1
刊名	FITOTERAPIA
	2019-10-01
卷号	138页码:7
关键词	Melodinus tenuicaudatus Monoterpenoid indole alkaloids Melotenuines A-E Aspidosperma-meloscandonine type
ISSN号	0367-326X
DOI	10.1016/j.fitote.2019.104347
通讯作者	He, Hong-Ping(hehongping@yahoo.com) ; Zhang, Yu(zhangyu@mail.kib.ac.cn)
英文摘要	Five new monoterpenoid indole alkaloids, melotenuines A-E (1-5), along with 18 known indole alkaloids, were isolated from the twigs and leaves of Melodinus tenuicaudatus. The structures of the new alkaloids were determined by a combination of MS, NMR and ECD analysis. Melotenuine A (1) represents the first example of aspidosperma-meloscandonine type bisindole alkaloids characterized by a methylene bridge between the two monomers, while melotenuine B (2) possessed a rare eburnamine-melsocandonine skeleton. All of the new indole alkaloids were evaluated for in vitro cytotoxicities against five human cancer cell lines. Among them, alkaloid 4 showed specific cytotoxicity against HL-60 cell line with IC 50 value (5.15 +/- 0.16 mu M) comparable with that of positive control.
WOS研究方向	Pharmacology & Pharmacy
语种	英语
WOS记录号	WOS:000498290700022
内容类型	期刊论文
源URL	[http://ir.kib.ac.cn/handle/151853/70469]
专题	昆明植物研究所_植物化学与西部植物资源持续利用国家重点实验室
通讯作者	He, Hong-Ping; Zhang, Yu
作者单位	1.Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China 2.Yunnan Univ Tradit Chinese Med, Kunming 650500, Yunnan, Peoples R China
推荐引用方式 GB/T 7714	Liu, Jian-Wen,Huo, Zong-Qing,Zhao, Qian,et al. Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus[J]. FITOTERAPIA,2019,138:7.
APA	Liu, Jian-Wen,Huo, Zong-Qing,Zhao, Qian,Hao, Xiao-Jiang,He, Hong-Ping,&Zhang, Yu.(2019).Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus.FITOTERAPIA,138,7.
MLA	Liu, Jian-Wen,et al."Melotenuines A-E, cytotoxic monoterpenoid indole alkaloids from Melodinus tenuicaudatus".FITOTERAPIA 138(2019):7.

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