Structural and functional underpinnings of precentral abnormalities in amyotrophic lateral sclerosis | |
Cheng, Luqi1; Yuan, Yumin2; Tang, Xie1; Zhou, Yuan3,4; Luo, Chunxia5; Liu, Daihong6,7; Zhang, Yuanchao1; Zhang, Jiuquan6,7 | |
刊名 | EUROPEAN JOURNAL OF NEUROLOGY |
2021-02-01 | |
页码 | 9 |
关键词 | amyotrophic lateral sclerosis cortical thickness effective connectivity precentral gyrus spectral dynamic causal modelling |
ISSN号 | 1351-5101 |
DOI | 10.1111/ene.14717 |
产权排序 | 3 |
文献子类 | 实证研究 |
英文摘要 | Background and purpose: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by the loss of both upper and lower motor neurons. Studies using various magnetic resonance imaging (MRI) analytical approaches have consistently identified significant precentral abnormalities in ALS, whereas their structural and functional underpinnings remain poorly understood. Methods: Using cortical thickness, fractional anisotropy (FA), and effective connectivity, we performed a multimodal MRI study to examine the structural and functional alterations associated with precentral abnormalities in patients with ALS (n = 60) compared with healthy controls (n = 60). Results: Cortical thickness analysis revealed significant cortical thinning in the right precentral gyrus (PCG), superior frontal gyrus, and superior temporal gyrus in patients with ALS. Tractwise white matter microstructure analyses revealed decreased FA in the tracts connected to the PCG cluster in patients with ALS involving the right corticospinal tract and the middle posterior body of the corpus callosum. Additionally, the cortical thickness of the PCG cluster was found to be positively correlated with FA of the tracts connected to the PCG cluster, suggesting that these two structural features are tightly coupled. Using spectral dynamic causal modelling, effective connectivity analysis among the three regions with cortical thinning revealed decreased self-inhibitory influence in the PCG cluster in patients with ALS, which might be an endophenotypic manifestation of an imbalance in inhibitory and excitatory neurotransmitters in this region. Conclusions: The present data shed new light on the structural and functional underpinnings of precentral abnormalities in ALS. |
资助项目 | National Natural Science Foundation of China[82071883] ; combination projects in medicine and engineering of the Fundamental Research Funds of the Central Universities in 2019[2019CDYGYB008] ; Chongqing Key Medical Research Project of Combination of Science and Medicine[2019ZDXM007] ; 2019 SKY Imaging Research Fund of the Chinese International Medical Foundation[Z-2014-07-1912-10] |
WOS研究方向 | Neurosciences & Neurology |
语种 | 英语 |
出版者 | WILEY |
WOS记录号 | WOS:000613526100001 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/38467] |
专题 | 心理研究所_中国科学院行为科学重点实验室 |
通讯作者 | Zhang, Yuanchao; Zhang, Jiuquan |
作者单位 | 1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Minist Educ, Key Lab Neuroinformat, Chengdu, Peoples R China 2.Chongqing Univ Sci & Technol, Sch Intelligent Technol & Engn, Chongqing, Peoples R China 3.Inst Psychol, CAS Key Lab Behav Sci, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Third Mil Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing, Peoples R China 6.Chongqing Univ, Canc Hosp, Chongqing Canc Inst, Dept Radiol, Chongqing, Peoples R China 7.Chongqing Canc Hosp, Chongqing 400030, Peoples R China |
推荐引用方式 GB/T 7714 | Cheng, Luqi,Yuan, Yumin,Tang, Xie,et al. Structural and functional underpinnings of precentral abnormalities in amyotrophic lateral sclerosis[J]. EUROPEAN JOURNAL OF NEUROLOGY,2021:9. |
APA | Cheng, Luqi.,Yuan, Yumin.,Tang, Xie.,Zhou, Yuan.,Luo, Chunxia.,...&Zhang, Jiuquan.(2021).Structural and functional underpinnings of precentral abnormalities in amyotrophic lateral sclerosis.EUROPEAN JOURNAL OF NEUROLOGY,9. |
MLA | Cheng, Luqi,et al."Structural and functional underpinnings of precentral abnormalities in amyotrophic lateral sclerosis".EUROPEAN JOURNAL OF NEUROLOGY (2021):9. |
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