mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress | |
Xu, Hang1; Wang, Jiesi1; Jing, Haiyang1,4; Ellenbroek, Bart3; Shao, Feng2; Wang, Weiwen1,4 | |
刊名 | NEUROPHARMACOLOGY |
2021-02-15 | |
卷号 | 184页码:10 |
关键词 | Adolescent social stress Depression Cognitive dysfunction Anxiety Brain-derived neurotrophic factor (BDNF) GABAergic transmission |
ISSN号 | 0028-3908 |
DOI | 10.1016/j.neuropharm.2020.108412 |
产权排序 | 1 |
文献子类 | 实证研究 |
英文摘要 | Depression with comorbid anxiety or cognitive symptoms can vary in terms of symptoms, pathophysiology and antidepressant efficacy, but the underlying neurobiological mechanisms remain to be elucidated. Previous studies from our group and others have shown that as a classic animal model of depression, adolescent social stress (ASS) could stably induce a variety of emotional and cognitive alterations in adult animals, and accompanied by transcriptional decrease in brain-derived neurotrophic factor (BDNF) total and promoter IV levels in the medial prefrontal cortex (mPFC). The present study further identified the GABAergic synaptic and molecular changes downstream of BDNF signaling impairment in the mPFC and roles in various behavioral phenotypes induced by ASS. We found that ASS induced a set of emotional and cognitive symptoms, including decreased social interest, impaired cognitive function, and increased anxiety-like behavior, as well as decreased GABAergic transmission in the mPFC. The specific deletion of BDNF promoter IV directly caused impairments in social interest, cognitive function, and inhibition of GABAergic transmission, but no changes in anxiety-like behavior. Acute microinjections of tropomyosin-related kinase B (TrkB) agonists into the mPFC and chronic antidepressant treatment ameliorated the changes in social behavior and cognition, as well as the reduction in GABAergic synaptic transmission in the mPFC, but not anxiety in previously stressed adult mice. These results suggest that the downstream GABAergic transmission of BDNF signaling in the mPFC involved in depression with comorbid cognitive dysfunction induced by ASS and can be used as a therapeutic target for the treatment of cognitive dysfunction in depression. This article is part of the special issue on Stress, Addiction and Plasticity. |
WOS关键词 | DEPRESSION ; INTERNEURONS ; BEHAVIOR ; TRKB ; TRANSCRIPTION ; NEURONS ; IMPACT ; COMORBIDITY ; ACTIVATION ; EXPRESSION |
WOS研究方向 | Neurosciences & Neurology ; Pharmacology & Pharmacy |
语种 | 英语 |
出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
WOS记录号 | WOS:000614900500008 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/38586] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Wang, Weiwen |
作者单位 | 1.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China 2.Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China 3.Victoria Univ Wellington, Sch Psychol, Wellington 6012, New Zealand 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Xu, Hang,Wang, Jiesi,Jing, Haiyang,et al. mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress[J]. NEUROPHARMACOLOGY,2021,184:10. |
APA | Xu, Hang,Wang, Jiesi,Jing, Haiyang,Ellenbroek, Bart,Shao, Feng,&Wang, Weiwen.(2021).mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress.NEUROPHARMACOLOGY,184,10. |
MLA | Xu, Hang,et al."mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress".NEUROPHARMACOLOGY 184(2021):10. |
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