Altered cerebellocerebral structural covariance in individuals with attenuated psychosis syndrome | |
Pu, Chengcheng2; Wang, Yi3,4; Zheng, Hong3,4; Shi, Chuan2; Cheung, Eric F. C.1; Chan, Raymond C. K.3,4; Yu, Xin2 | |
刊名 | ASIAN JOURNAL OF PSYCHIATRY |
2020-10-01 | |
卷号 | 53页码:7 |
关键词 | Voxel-based morphometric analysis Attenuated psychosis syndrome Cerebellum Structural covariance Prefrontal cortex |
ISSN号 | 1876-2018 |
DOI | 10.1016/j.ajp.2020.102238 |
产权排序 | 2 |
文献子类 | 实证研究 |
英文摘要 | Background: Reduced cerebellar volumes and altered cerebellocerebral structural covariance have been reported in patients with schizophrenia. However, it is not clear whether such altered cerebellocerebral structural covariance would be observed before the onset of psychosis. We examined brain structural changes, including cerebral and cerebellar volumes, and cerebellocerebral structural covariance in individuals with attenuated psychosis syndrome (APS). Materials and methods: Twenty-one individuals with APS and 24 healthy controls (HC) were recruited and underwent structural MRI brain scan. Differences in voxel-based grey matter (GM) volume and cerebellar volume between the APS and HC groups were examined. The correlation between cerebellar volumes and voxel-based cerebral GM volumes were calculated to measure cerebellocerebral structural covariance in each group followed by group comparisons. Results: Compared with HC, individuals with APS exhibited extensive GM volume reduction in the frontal and striatal areas and reduced cerebellar volume. Structural covariance analysis indicated that the anterior and posterior parts of the cerebellum showed disparate correlation with cerebral voxel-based GM volumes. Abnormal cerebellar-cerebral correlation was also found in individuals with APS at the medial prefrontal gyrus. Conclusions: Our findings suggest that prefrontal and striatal structural changes as well as cerebellar structural covariance at the medial prefrontal gyrus may underpin the risk for psychosis and may serve as a potential target for early intervention in individuals at-risk for psychosis. |
资助项目 | Capital's Funds for Health Improvement and Research (CFH)[2018-4-4116] ; Key Program of Beijing Science and Technology Commission[D121100005012004] ; National Science Fund China[31871114] ; National Science Fund China[31400884] ; Beijing Municipal Science & Technology Commission[Z161100000216138] ; Beijing Training Project for the Leading Talents in Science and Technology[Z151100000315020] ; China Scholarship Council ; CAS Key Laboratory of Mental Health, Institute of Psychology |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER |
WOS记录号 | WOS:000595918300018 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/38334] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Chan, Raymond C. K.; Yu, Xin |
作者单位 | 1.Castle Peak Hosp, Hong Kong, Peoples R China 2.Peking Univ, Peking Univ Sixth Hosp, Peking Univ Inst Mental Hlth, NHC Key Lab Mental Hlth,Natl Clin Res Ctr Mental, Beijing, Peoples R China 3.Chinese Acad Sci, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Inst Psychol, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Pu, Chengcheng,Wang, Yi,Zheng, Hong,et al. Altered cerebellocerebral structural covariance in individuals with attenuated psychosis syndrome[J]. ASIAN JOURNAL OF PSYCHIATRY,2020,53:7. |
APA | Pu, Chengcheng.,Wang, Yi.,Zheng, Hong.,Shi, Chuan.,Cheung, Eric F. C..,...&Yu, Xin.(2020).Altered cerebellocerebral structural covariance in individuals with attenuated psychosis syndrome.ASIAN JOURNAL OF PSYCHIATRY,53,7. |
MLA | Pu, Chengcheng,et al."Altered cerebellocerebral structural covariance in individuals with attenuated psychosis syndrome".ASIAN JOURNAL OF PSYCHIATRY 53(2020):7. |
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