Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia | |
Yang, Mi1,2,3; Gao, Shan2; Zhang, Xiangyang4,5 | |
刊名 | TRANSLATIONAL PSYCHIATRY |
2020-11-02 | |
卷号 | 10期号:1页码:8 |
ISSN号 | 2158-3188 |
DOI | 10.1038/s41398-020-01049-0 |
产权排序 | 4 |
文献子类 | 实证研究 |
英文摘要 | Cognitive impairment is viewed as a core symptom of schizophrenia (SCZ), but its pathophysiological mechanism remains unclear. White matter (WM) disruption is considered to be a central abnormality that may contribute to cognitive impairment in SCZ patients. However, few studies have addressed the association between cognition and WM integrity in never-treated first-episode (NTFE) patients with SCZ. In this study, we used the MATRICS Consensus Cognitive Battery (MCCB) to evaluate cognitive function in NTFE patients (n=39) and healthy controls (n=30), and associated it with whole-brain fractional anisotropy (FA) values obtained via voxel-based diffusion tensor imaging. We found that FA was lower in five brain areas of SCZ patients, including the cingulate gyrus, internal capsule, corpus callosum, cerebellum, and brainstem. Compared with the healthy control group, the MCCB's total score and 8 out of 10 subscores were significantly lower in NTFE patients (all p<0.001). Moreover, in patients but not healthy controls, the performance in the Trail Making Test was negatively correlated with the FA value in the left cingulate. Our findings provide evidence that WM disconnection is involved in some cognitive impairment in the early course of SCZ. |
资助项目 | National Natural Science Foundation of China[61806042] ; National Natural Science Foundation of China[31600880] |
WOS关键词 | DIFFUSION TENSOR ; FRACTIONAL ANISOTROPY ; WORKING-MEMORY ; STRUCTURAL CONNECTIVITY ; INTEGRITY ; MICROSTRUCTURE ; IMPAIRMENT ; SYMPTOMS ; DISORDER ; BATTERY |
WOS研究方向 | Psychiatry |
出版者 | SPRINGERNATURE |
WOS记录号 | WOS:000589695200003 |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/33460] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Gao, Shan; Zhang, Xiangyang |
作者单位 | 1.Univ Elect Sci & Technol China, Sch Life Sci & Technol, Chengdu, Peoples R China 2.Univ Elect Sci & Technol China, Key Lab NeuroInformat, MOE, Chengdu Brain Sci Inst,Clin Hosp, Chengdu, Peoples R China 3.Fourth Peoples Hosp Chengdu, Chengdu, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing, Peoples R China |
推荐引用方式 GB/T 7714 | Yang, Mi,Gao, Shan,Zhang, Xiangyang. Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia[J]. TRANSLATIONAL PSYCHIATRY,2020,10(1):8. |
APA | Yang, Mi,Gao, Shan,&Zhang, Xiangyang.(2020).Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia.TRANSLATIONAL PSYCHIATRY,10(1),8. |
MLA | Yang, Mi,et al."Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia".TRANSLATIONAL PSYCHIATRY 10.1(2020):8. |
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