Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study | |
Wang, Ya11,12,13; Harding, Ian H.9,10,12,13; Testa, Renee1,8,9,12,13; Tonge, Bruce7; Jones, Harvey6; Seal, Marc5; Ross, Nola8; Chan, Raymond C. K.11; van Beurden, Florian12,13; Abu-Akel, Ahmad4 | |
刊名 | NPJ SCHIZOPHRENIA |
2020-03-18 | |
卷号 | 6期号:1页码:4 |
DOI | 10.1038/s41537-020-0095-7 |
产权排序 | 3 |
英文摘要 | Schizotypal disorder lies in the schizophrenia spectrum and is widely studied in adult populations. Schizotypal disorder in children (SDc) is less well described. This study examined brain morphological and functional connectivity abnormalities in SDc (12 SDc and 9 typically developing children), focusing on the default mode and executive control brain networks. Results indicated that SDc is associated with reduced grey matter volume (GMV) in superior and medial frontal gyri, and increased resting-state functional connectivity between the superior frontal gyrus and inferior parietal lobule, compared to typically developing children (cluster-level FWE-corrected p < 0.05). The brain structure abnormality (GMV in left superior frontal gyrus) was correlated with clinical symptoms in SDc (r = -0.66, p = 0.026) and functional connectivity abnormality was correlated with extra-dimensional shifting impairments in all participants (r = 0.62, p = 0.011), suggesting their contribution to the underlying mechanisms of clinical presentation. These preliminary results motivate further work to characterize the neural basis of SDc and its significance as a risk factor for later psychosis. |
WOS关键词 | PERSONALITY-DISORDER ; DEFAULT MODE ; WORKING-MEMORY ; SCHIZOPHRENIA ; NETWORK ; CONNECTIVITY ; CHILDHOOD ; PSYCHOSIS ; ONSET ; RISK |
WOS研究方向 | Psychiatry |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000520616600001 |
资助机构 | University of Melbourne Research Grant Support Scheme ; NHMRC Senior Principal Research Fellowship ; Brain and Behavior Research Foundation (NARSAD) Distinguished Investigator Award (US) ; Lundbeck Foundation ; NHMRC Early Career Fellowship ; China Scholarship Council |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/31460] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Pantelis, Christos |
作者单位 | 1.Royal Childrens Hosp, Mental Hlth Dept, Parkville, Vic, Australia 2.Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia 3.Univ Melbourne, Dept Elect & Elect Engn, Parkville, Vic, Australia 4.Univ Lausanne, Inst Psychol, Lausanne, Switzerland 5.Murdoch Childrens Res Inst, Parkville, Vic, Australia 6.Epworth HealthCare, Dept Psychol, Richmond, Vic, Australia 7.Monash Univ, Sch Clin Sci, Ctr Dev Psychiat & Psychol, Clayton, Vic, Australia 8.Child & Adolescent Neuropsychol Grp, East Melbourne, Vic, Australia 9.Monash Univ, Sch Psychol Sci, Clayton, Vic, Australia 10.Monash Univ, Turner Inst Brain & Mental Hlth, Clayton, Vic, Australia |
推荐引用方式 GB/T 7714 | Wang, Ya,Harding, Ian H.,Testa, Renee,et al. Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study[J]. NPJ SCHIZOPHRENIA,2020,6(1):4. |
APA | Wang, Ya.,Harding, Ian H..,Testa, Renee.,Tonge, Bruce.,Jones, Harvey.,...&Pantelis, Christos.(2020).Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study.NPJ SCHIZOPHRENIA,6(1),4. |
MLA | Wang, Ya,et al."Structural and functional brain abnormalities in children with schizotypal disorder: a pilot study".NPJ SCHIZOPHRENIA 6.1(2020):4. |
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