Altered brain white matter microstructural asymmetry in children with ADHD | |
Wu, Zhao-Min1,2,5,6,7; Wang, Peng6,7; Yang, Li6,7; Liu, Lu6,7; Sun, Li6,7; An, Li6,7; Cao, Qing-Jiu6,7; Chan, Raymond C. K.3,4; Yang, Bin-Rang5; Wang, Yu-Feng6,7 | |
刊名 | PSYCHIATRY RESEARCH |
2020-03-01 | |
卷号 | 285页码:6 |
关键词 | White matter Asymmetry ADHD |
ISSN号 | 0165-1781 |
DOI | 10.1016/j.psychres.2020.112817 |
产权排序 | 5 |
文献子类 | article |
英文摘要 | Objectives: We aimed to examine brain white matter integrity in children with ADHD. Methods: In a cohort of children with ADHD (n = 83) and healthy controls (n = 122), we used tract-based spatial statistics on Diffusion Tensor Imaging (DTI) data to obtain the mean fractional anisotropy (FA) in 40 bilateral regions of interest (ROIs). Lateralization Index (LI) was calculated. The difference in LI between groups and correlations between the LI of each ROI and ADHD symptom scores as well as cognitive function were examined. Results: Children with ADHD had significantly greater LI at the posterior thalamic radiation (PTR) compared with healthy controls (mean LI in ADHD = 0.0096; in Control = 0.0044, p = 0.0143), and LI of the external capsule (EC) was significantly correlated with inattention symptoms in both groups (beta = - 0.00059, p = 0.0181). LI of the PTR was significantly correlated with inhibitory function in healthy controls (beta = - 0.0008510, p = 0.0248), but not in children with ADHD. Conclusion: We found increased brain white matter asymmetry (leftward) in children with ADHD compared with healthy controls at the posterior thalamic radiation. Leftward lateralization of FA values at the external capsule was negatively correlated with ADHD symptoms in both children with ADHD and healthy controls. |
资助项目 | Sanming Project of Medicine in Shenzhen The ADHD research group from Peking University Sixth hospital[SZSM201612036] ; National Basic Research Program of China (973 program)[2014CB846104] |
WOS关键词 | DEFICIT HYPERACTIVITY DISORDER ; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; STRUCTURAL CONNECTIVITY ; SPATIAL STATISTICS ; VOLUME |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | ELSEVIER IRELAND LTD |
WOS记录号 | WOS:000518866900019 |
资助机构 | Sanming Project of Medicine in Shenzhen The ADHD research group from Peking University Sixth hospital ; National Basic Research Program of China (973 program) |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/31385] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Wu, Zhao-Min; Wang, Yu-Feng |
作者单位 | 1.Radboud Univ Nijmegen, Med Ctr, Dept Human Genet, Nijmegen, Netherlands 2.Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands 3.Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing, Peoples R China 4.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 5.Shenzhen Childrens Hosp, Shenzhen 518000, Peoples R China 6.Peking Univ, Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China 7.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China |
推荐引用方式 GB/T 7714 | Wu, Zhao-Min,Wang, Peng,Yang, Li,et al. Altered brain white matter microstructural asymmetry in children with ADHD[J]. PSYCHIATRY RESEARCH,2020,285:6. |
APA | Wu, Zhao-Min.,Wang, Peng.,Yang, Li.,Liu, Lu.,Sun, Li.,...&Wang, Yu-Feng.(2020).Altered brain white matter microstructural asymmetry in children with ADHD.PSYCHIATRY RESEARCH,285,6. |
MLA | Wu, Zhao-Min,et al."Altered brain white matter microstructural asymmetry in children with ADHD".PSYCHIATRY RESEARCH 285(2020):6. |
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