Association between decreased HDL levels and cognitive deficits in patients with bipolar disorder: a pilot study | |
Hui, Li1,2,3,4; Yin, Xiao Li2; Chen, Jie1; Yin, Xu Yuan1; Zhu, Hong Liang1; Li, Jin1; Yin, Guang Zhong1; Xu, Xiao Wen1; Yang, Xiao Nan1; Qian, Zheng Kang1 | |
刊名 | INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS |
2019-12-01 | |
卷号 | 7期号:1页码:7 |
关键词 | High density lipoprotein Bipolar disorder Cognition RBANS |
ISSN号 | 2194-7511 |
DOI | 10.1186/s40345-019-0159-7 |
英文摘要 | Background Cognitive deficits are common in patients with bipolar disorder (BD). Abnormal high density lipoprotein (HDL) levels have been implicated in cognitive deficits associated with ageing and neurodegenerative disorders. The present study aimed to investigate serum HDL levels, cognitive deficits and their association in patients with BD. Methods Thirty-seven patients with BD and 37 gender- and age-matched healthy controls (HCs) were recruited in a case-control study. Cognition was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), and serum HDL levels were measured using enzymatic colourimetry. Results There was no difference in serum HDL levels between patients with BD and HCs after adjusting for gender, age, education and body mass index (BMI). Cognitive test scores in patients with BD were significantly lower than those in HCs except for the visuospatial/constructional index after adjusting for confounding variables. Serum HDL levels were positively correlated with RBANS total score and language score in patients with BD. Stepwise multiple regression analysis showed that serum HDL levels were significantly correlated with RBANS total score and subscale scores on immediate memory and language in patients with BD after adjusting for confounding factors. Conclusions Our findings suggest that patients with BD had poorer cognitive performance than HCs except for the visuospatial/constructional domain, and decreased serum HDL levels were correlated with cognitive deficits, especially in immediate memory and language domains in patients with BD. |
资助项目 | National Natural Science Foundation of China[81771439] ; National Natural Science Foundation of China[81501160] ; Jiangsu High-level Health Talent Project[LGY2018010] ; Jiangsu High-level Health Talent Project[QNRC2016228] ; Jiangsu Six Talent Peaks Project[WSN-165] ; Jiangsu Key Research and Development Program[BE2018662] ; Suzhou Medical Key Subject[Szxk201815] ; Suzhou Medical Key Subject[Szxk201515] ; Suzhou Key Diagnosis and Treatment Program[LCZX201820] ; Suzhou Key Diagnosis and Treatment Program[LCZX201615] ; Suzhou Key Diagnosis and Treatment Program[LCZX201515] ; Suzhou Key Laboratory for Biological Psychiatry[SZS201722] ; Suzhou Key Medical Center for Psychiatric Diseases[Szzx201509] ; Suzhou Sci-Tech Bureau Program[SS201706] ; Suzhou Sci-Tech Bureau Program[SYS201578] ; Suzhou Health City 531 Action Plan ; Zhejiang Province Rising Star in Medicine ; CAS Key Laboratory of Mental Health, Institute of Psychology[KLMH2019K03] |
WOS关键词 | HIGH-DENSITY-LIPOPROTEIN ; APOLIPOPROTEIN-A-I ; NEUROPSYCHOLOGICAL STATUS RBANS ; REPEATABLE BATTERY ; 1ST-DEGREE RELATIVES ; EUTHYMIC PATIENTS ; MOUSE MODEL ; CHOLESTEROL ; SCHIZOPHRENIA ; PERFORMANCE |
WOS研究方向 | Psychiatry |
语种 | 英语 |
出版者 | SPRINGEROPEN |
WOS记录号 | WOS:000500395200001 |
资助机构 | National Natural Science Foundation of China ; Jiangsu High-level Health Talent Project ; Jiangsu Six Talent Peaks Project ; Jiangsu Key Research and Development Program ; Suzhou Medical Key Subject ; Suzhou Key Diagnosis and Treatment Program ; Suzhou Key Laboratory for Biological Psychiatry ; Suzhou Key Medical Center for Psychiatric Diseases ; Suzhou Sci-Tech Bureau Program ; Suzhou Health City 531 Action Plan ; Zhejiang Province Rising Star in Medicine ; CAS Key Laboratory of Mental Health, Institute of Psychology |
内容类型 | 期刊论文 |
源URL | [http://ir.psych.ac.cn/handle/311026/30516] |
专题 | 心理研究所_中国科学院心理健康重点实验室 |
通讯作者 | Hui, Li; Chan, Raymond C. K.; Jia, Qiu Fang |
作者单位 | 1.Soochow Univ, Affiliated Guangji Hosp, Suzhou Guangji Hosp, Inst Mental Hlth, 11 Guangqian Rd, Suzhou 215137, Jiangsu, Peoples R China 2.Wenzhou Med Univ, Wenzhou Kangning Hosp, Wenzhou, Zhejiang, Peoples R China 3.Inst Psychiat, Neuropsychol & Appl Cognit Neurosci Lab, CAS Key Lab Mental Hlth, Beijing, Peoples R China 4.Suzhou Ctr Dis Control & Prevent, Suzhou, Jiangsu, Peoples R China 5.Castle Peak Hosp, Hong Kong, Peoples R China 6.Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China 7.Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China |
推荐引用方式 GB/T 7714 | Hui, Li,Yin, Xiao Li,Chen, Jie,et al. Association between decreased HDL levels and cognitive deficits in patients with bipolar disorder: a pilot study[J]. INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS,2019,7(1):7. |
APA | Hui, Li.,Yin, Xiao Li.,Chen, Jie.,Yin, Xu Yuan.,Zhu, Hong Liang.,...&Jia, Qiu Fang.(2019).Association between decreased HDL levels and cognitive deficits in patients with bipolar disorder: a pilot study.INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS,7(1),7. |
MLA | Hui, Li,et al."Association between decreased HDL levels and cognitive deficits in patients with bipolar disorder: a pilot study".INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS 7.1(2019):7. |
个性服务 |
查看访问统计 |
相关权益政策 |
暂无数据 |
收藏/分享 |
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。
修改评论