Anticoagulant dialyzer with enhanced Ca2+ chelation and hydrophilicity for heparin free hemodialysis

doi:10.1016/j.memsci.2020.118082

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Anticoagulant dialyzer with enhanced Ca2+ chelation and hydrophilicity for heparin free hemodialysis
	Liu, Yang ; Li, Guiliang ; Han, Qiu ; Lin, Haibo ; Li, Qiang ; Hua, Jing ; Liu, Fu
刊名	JOURNAL OF MEMBRANE SCIENCE
	2020
卷号	604
关键词	CITRIC-ACID SURFACE COMPLEMENT ACTIVATION MECHANISM MEMBRANE HYDROGEL POLYMER SIZE
DOI	10.1016/j.memsci.2020.118082
英文摘要	Inhibiting thrombosis in extracorporeal dialyzer is predominantly determined by the compatible interface design. It is challenging to develop anticoagulant dialyzers for clinical heparin free dialysis. Herein, we develop an environmentally friendly approach to construct a hydrogel skin composed of poly (sodium alginate-acrylic acid) P (SA-AA) network on polysulfone (PSf) membranes via pre-seeding initiator into membrane matrix and subsequently crosslinking SA and AA in aqueous solution. Physicochemical properties of modified membranes with different SA/AA ratio were characterized by attenuated total reflectance fourier transform infrared spectra (ATR-FTIR) spectrum, proton nuclear magnetic resonance (C-13 NMR), scanning electron microscopy (SEM) and atomic force microscope (AFM) and contact angle. Antifouling property was demonstrated by proteins adsorption and E. coli adhesion. Hemocompatibility was comprehensively evaluated by hemolysis ratio, anticoagulation activity (APTT and TT), complement activation, platelets activation and contact activation. Anticoagulant dialyzer was fabricated via skin implantation strategy to implement a chronic renal swine dialysis with heparin free administration. Clotting was significantly inhibited during the whole dialysis session, moreover, the dialyzer showed improved toxins clearance, including urea (similar to 185 mL/min), creatine (similar to 153 mL/min), inorganic phosphorous (similar to 120 mL/min) and beta(2)-microglobulin (similar to 110 mL/min). The modified membrane bearing abundant carboxylate groups contributes to excellent hydrophilicity and Ca2+ chelation capability, which is considered to be the predominant anti-clotting mechanism via both intrinsic and extrinsic cascades. The anticoagulant PSf dialyzer demonstrates promising clinical application for heparin free dialysis.
学科主题	Engineering ; Polymer Science
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/20757]
专题	2020专题
作者单位	1.Hua, J (corresponding author), Qingdao Univ Sci & Technol, Key Lab Rubber Plast, Minist Educ, Shandong Prov Key Lab Rubber Plast, Qingdao 266042, Peoples R China. 2.Liu, F (corresponding author), Chinese Acad Sci, Ningbo Inst Mat Technol & Engn, Key Lab Biobased Polymer Mat Technol & Applicat Z, 1219 Zhongguan West Rd, Ningbo 315201, Peoples R China.
推荐引用方式 GB/T 7714	Liu, Yang,Li, Guiliang,Han, Qiu,et al. Anticoagulant dialyzer with enhanced Ca2+ chelation and hydrophilicity for heparin free hemodialysis[J]. JOURNAL OF MEMBRANE SCIENCE,2020,604.
APA	Liu, Yang.,Li, Guiliang.,Han, Qiu.,Lin, Haibo.,Li, Qiang.,...&Liu, Fu.(2020).Anticoagulant dialyzer with enhanced Ca2+ chelation and hydrophilicity for heparin free hemodialysis.JOURNAL OF MEMBRANE SCIENCE,604.
MLA	Liu, Yang,et al."Anticoagulant dialyzer with enhanced Ca2+ chelation and hydrophilicity for heparin free hemodialysis".JOURNAL OF MEMBRANE SCIENCE 604(2020).