The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice

doi:10.1038/s41598-020-66192-6

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	The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice
	Burwood, George W. S.; Dziennis, Suzan; Wilson, Teresa; Foster, Sarah; Zhang, Yuan; Liu, Gangjun; Yang, Jianlong; Elkins, Sean; Nuttall, Alfred L.
刊名	SCIENTIFIC REPORTS
	2020
卷号	10 期号:1
关键词	OUTER HAIR-CELLS LATERAL WALL HEARING-LOSS GUINEA-PIG ADRENERGIC-INNERVATION FLUID HOMEOSTASIS STIMULATION VELOCITY GANGLION EAR
DOI	10.1038/s41598-020-66192-6
英文摘要	The mammalian cochlea possesses unique acoustic sensitivity due to a mechanoelectrical 'amplifier', which requires the metabolic support of the cochlear lateral wall. Loud sound exposure sufficient to induce permanent hearing damage causes cochlear blood flow reduction, which may contribute to hearing loss. However, sensory epithelium involvement in the cochlear blood flow regulation pathway is not fully described. We hypothesize that genetic manipulation of the mechanoelectrical transducer complex will abolish sound induced cochlear blood flow regulation. We used salsa mice, a Chd23 mutant with no mechanoelectrical transduction, and deafness before p56. Using optical coherence tomography angiography, we measured the cochlear blood flow of salsa and wild-type mice in response to loud sound (120dB SPL, 30minutes low-pass filtered noise). An expected sound induced decrease in cochlear blood flow occurred in CBA/CaJ mice, but surprisingly the same sound protocol induced cochlear blood flow increases in salsa mice. Blood flow did not change in the contralateral ear. Disruption of the sympathetic nervous system partially abolished the observed wild-type blood flow decrease but not the salsa increase. Therefore sympathetic activation contributes to sound induced reduction of cochlear blood flow. Additionally a local, non-sensory pathway, potentially therapeutically targetable, must exist for cochlear blood flow regulation.
学科主题	Science & Technology - Other Topics
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/20744]
专题	2020专题
作者单位	Nuttall, AL (corresponding author), Oregon Hlth & Sci Univ, Oregon Hearing Res Ctr, Dept Otolaryngol HNS, 3250 SW Sam Jackson Pk Rd, Portland, OR 97239 USA.
推荐引用方式 GB/T 7714	Burwood, George W. S.,Dziennis, Suzan,Wilson, Teresa,et al. The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice[J]. SCIENTIFIC REPORTS,2020,10(1).
APA	Burwood, George W. S..,Dziennis, Suzan.,Wilson, Teresa.,Foster, Sarah.,Zhang, Yuan.,...&Nuttall, Alfred L..(2020).The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice.SCIENTIFIC REPORTS,10(1).
MLA	Burwood, George W. S.,et al."The mechanoelectrical transducer channel is not required for regulation of cochlear blood flow during loud sound exposure in mice".SCIENTIFIC REPORTS 10.1(2020).