Tandem post-synthetic modification of a zeolitic imidazolate framework for CXCR4-overexpressed esophageal squamous cell cancer imaging and therapy

doi:10.1039/d0nr00895h

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Tandem post-synthetic modification of a zeolitic imidazolate framework for CXCR4-overexpressed esophageal squamous cell cancer imaging and therapy
	Cao, Yi ; Jiang, Zhenqi ; Li, Yanying ; Wang, Yinjie ; Yang, Yong ; Akakuru, Ozioma Udochukwu ; Li, Juan ; Wu, Aiguo
刊名	NANOSCALE
	2020
卷号	12 期号:24 页码:12779-12789
关键词	METAL-ORGANIC FRAMEWORKS LYMPH-NODE METASTASIS PREOPERATIVE CHEMORADIOTHERAPY FAVORABLE BIOCOMPATIBILITY CXCR4 EXPRESSION AMPLIFICATION PATTERNS BINDING
DOI	10.1039/d0nr00895h
英文摘要	Zeolitic imidazolate frameworks (ZIFs) as emerging porous materials have attracted remarkable attention for their unprecedented porosity and acidic sensitive degradation that enables high drug loading and microenvironment responsive fast payload release. However, the limited functions and disadvantages of ZIF5 such as early drug release, potential cytotoxicity inducing damage to major organs, and even death of animals, impede their further biomedical application. In this work, we report the first tandem post-synthetic modification of ZIF-7 with both metal ions and organic ligands. Inspired by the benzimidazole-like inhibitors that are similar to the organic ligand of ZIF-7, a chemokine (C-X-C motif) receptor 4 (CXCR4) inhibitor AMD-070 (AMD) and magnesium ions (Mn2+) were successfully tandem exchanged to the ZIF-7 framework, forming an active-targeting framework AMD-ZIF-7(Mn) for CXCR4-overexpressed esophageal squamous cell cancer. The obtained AMD-ZIF-7(Mn) showed good biocompatibility in vitro and in vivo. Meanwhile, it exhibited an excellent T-1-weighted magnetic resonance imaging performance and CXCR4 targeting ability. With 5-Fu loading, AMD-ZIF-7(Mn)/5-Fu showed a synergistic therapeutic effect in DNA damage and CXCR4 inhibition of esophageal squamous cell cancer. Therefore, we propose a structural reconstruction method to effectively explore and improve the biomedical application of ZIF5 in esophageal squamous cell cancer theranostics.
学科主题	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/20696]
专题	2020专题
作者单位	1.Wu, AG (corresponding author), Chinese Acad Sci, CAS Key Lab Magnet Mat & Devices, Zhejiang Engn Res Ctr Biomed Mat, Cixi Inst Biomed Engn,Ningbo Inst Mat Technol & E, Ningbo 315201, Peoples R China. 2.Li, J
推荐引用方式 GB/T 7714	Cao, Yi,Jiang, Zhenqi,Li, Yanying,et al. Tandem post-synthetic modification of a zeolitic imidazolate framework for CXCR4-overexpressed esophageal squamous cell cancer imaging and therapy[J]. NANOSCALE,2020,12(24):12779-12789.
APA	Cao, Yi.,Jiang, Zhenqi.,Li, Yanying.,Wang, Yinjie.,Yang, Yong.,...&Wu, Aiguo.(2020).Tandem post-synthetic modification of a zeolitic imidazolate framework for CXCR4-overexpressed esophageal squamous cell cancer imaging and therapy.NANOSCALE,12(24),12779-12789.
MLA	Cao, Yi,et al."Tandem post-synthetic modification of a zeolitic imidazolate framework for CXCR4-overexpressed esophageal squamous cell cancer imaging and therapy".NANOSCALE 12.24(2020):12779-12789.