Boron-Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides

doi:10.1002/chem.201905083

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Boron-Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides
	Bregadze, Vladimir I.; Sivaev, Igor B.; Dubey, Ravindra Dhar ; Semioshkin, Andrey ; Shmal'ko, Akim V.; Kosenko, Irina D.; Lebedeva, Kseniya V.; Mandal, Swadhin ; Sreejyothi, Prasannakumar ; Sarkar, Arindam
刊名	CHEMISTRY-A EUROPEAN JOURNAL
	2020
卷号	26 期号:61 页码:13832-13841
关键词	NEUTRON-CAPTURE THERAPY CLOSO-DODECABORATE ANION TARGETED LIPOSOMES OXONIUM DERIVATIVES CLUSTER LIPIDS DELIVERY AGENTS MURINE TUMORS ORAL-CANCER CHEMISTRY BIS(DICARBOLLIDES)
DOI	10.1002/chem.201905083
英文摘要	A series of boron-containing lipids were prepared by reactions of cyclic oxonium derivatives of polyhedron boranes and metallacarboranes (closo-dodecaborate anion, cobalt and iron bis(dicarbollides)) with amine and carboxylic acids which are derived from cholesterol. Stable liposomal formulations, on the basis of synthesized boron-containing lipids, hydrogenated soybeanl-alpha-phosphatidylcholine and (HSPC) 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000] (DSPE-PEG) as excipients, were prepared and then characterized by dynamic light scattering (DLS) that revealed the formation of particles to be smaller than 200 nm in diameter. The resulting liposomal formulations showed moderate to excellent loading and entrapment efficiency, thus justifying the design of the compounds to fit in the lipid bilayer and ensuring ease of in vivo use for future application. The liposomal formulations based on cobalt and iron bis(dicarbollide)-based lipids were found to be nontoxic against both human breast normal epithelial cells MCF-10A and human breast cancer cells MCF-7.
学科主题	Chemistry
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/20439]
专题	2020专题
作者单位	1.Sarkar, A (corresponding author), India Innovat Res Ctr, 465 Patparganj Ind Area, Delhi 110092, India. 2.Shen, ZY (corresponding author), Southern Med Univ, Guangdong Prov Key Lab Construct & Detect Tissue, Biomat Res Ctr, Sch Biomed Engn, Guangzhou 510515, Peoples R China. 3.Bregadze, VI (corresponding author), Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, 28 Vavilov Str, Moscow 119991, Russia.
推荐引用方式 GB/T 7714	Bregadze, Vladimir I.,Sivaev, Igor B.,Dubey, Ravindra Dhar,et al. Boron-Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides[J]. CHEMISTRY-A EUROPEAN JOURNAL,2020,26(61):13832-13841.
APA	Bregadze, Vladimir I..,Sivaev, Igor B..,Dubey, Ravindra Dhar.,Semioshkin, Andrey.,Shmal'ko, Akim V..,...&Hosmane, Narayan S..(2020).Boron-Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides.CHEMISTRY-A EUROPEAN JOURNAL,26(61),13832-13841.
MLA	Bregadze, Vladimir I.,et al."Boron-Containing Lipids and Liposomes: New Conjugates of Cholesterol with Polyhedral Boron Hydrides".CHEMISTRY-A EUROPEAN JOURNAL 26.61(2020):13832-13841.