Deep Penetration of Targeted Nanobubbles Enhanced Cavitation Effect on Thrombolytic Capacity

doi:10.1021/acs.bioconjchem.9b00653

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Deep Penetration of Targeted Nanobubbles Enhanced Cavitation Effect on Thrombolytic Capacity
	Ma, Ling ; Wang, Yinjie ; Zhang, Shengmin ; Qian, Xuechen ; Xue, Nianyu ; Jiang, Zhenqi ; Akakuru, Ozioma Udochukwu ; Li, Juan ; Xu, Youfeng ; Wu, Aiguo
刊名	BIOCONJUGATE CHEMISTRY
	2020
卷号	31 期号:2 页码:369-374
关键词	LOW-FREQUENCY ULTRASOUND MICROBUBBLE CAVITATION IN-VITRO RT-PA ALPHA(IIB)BETA(3) UROKINASE
DOI	10.1021/acs.bioconjchem.9b00653
英文摘要	Sonothrombolysis with microbubbles can enhance the dissolution of thrombus through the cavitation effect of microbubbles under ultrasound irradiation. However, the detailed mechanism of thrombolysis with microscaled or nanoscaled bubbles is still not so clear. This study compared the thrombolytic capacity of cRGD-targeted or nontargeted bubbles with different particle sizes combined with urokinase (UK). The size of the microscaled bubbles (Mbs or Mbs-cRGD) was mostly approximately 3 mu m, while the nanoscaled bubbles (Nbs or Nbs-cRGD) were mainly around 220 nm. In vitro testing was performed on an extracorporeal circulation device that mimics human vascular thromboembolism. The rabbit clots in Mbs with UK groups showed peripheral worm-like dissolution, while the clots in Nbs with UK groups showed internal fissure-like collapse. In addition, the thrombolysis rate of Nbs-cRGD with the UK group was the highest. Furthermore, the scanning electron microscopic images showed that the fibrin network was the most severely damaged by the Nbs-cRGD, and most of the fibrin strands were dissolved. Especially, the Nbs-cRGD can penetrate much deeper than Mbs-cRGD into the thrombus and loosen the fibrin network. Taken together, benefiting from the specific identification and deep penetration to thrombus, our developed novel targeted Nbs may have broad application prospects in the clinic.
学科主题	Biochemistry & Molecular Biology ; Chemistry
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/20068]
专题	2020专题
作者单位	1.Wu, AG (corresponding author), Chinese Acad Sci, Key Lab Addit Mfg Mat Zhejiang Prov, CAS Key Lab Magnet Mat & Devices, Ningbo Inst Mat Technol & Engn,Cixi Inst Biomed E, Ningbo 315201, Peoples R China. 2.Xu, YF (corresponding author), Ningbo First Hosp, Dept Ultrasound, Ningbo 315010, Peoples R China. 3.Li, J
推荐引用方式 GB/T 7714	Ma, Ling,Wang, Yinjie,Zhang, Shengmin,et al. Deep Penetration of Targeted Nanobubbles Enhanced Cavitation Effect on Thrombolytic Capacity[J]. BIOCONJUGATE CHEMISTRY,2020,31(2):369-374.
APA	Ma, Ling.,Wang, Yinjie.,Zhang, Shengmin.,Qian, Xuechen.,Xue, Nianyu.,...&Wu, Aiguo.(2020).Deep Penetration of Targeted Nanobubbles Enhanced Cavitation Effect on Thrombolytic Capacity.BIOCONJUGATE CHEMISTRY,31(2),369-374.
MLA	Ma, Ling,et al."Deep Penetration of Targeted Nanobubbles Enhanced Cavitation Effect on Thrombolytic Capacity".BIOCONJUGATE CHEMISTRY 31.2(2020):369-374.