Ten-Gram-Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis

doi:10.1002/smll.201906870

CORC > 宁波材料技术与工程研究所 > 中国科学院宁波材料技术与工程研究所 > 2020专题

	Ten-Gram-Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis
	Wei, Zhenni ; Jiang, Zhenqi ; Pan, Chunshu ; Xia, Jianbi ; Xu, Kaiwei ; Xue, Ting ; Yuan, Bo ; Akakuru, Ozioma Udochukwu ; Zhu, Chengjie ; Zhang, Guilong
刊名	SMALL
	2020
卷号	16 期号:11
关键词	IRON-OXIDE NANOPARTICLES CONTRAST AGENTS MAGNETIC NANOPARTICLES THERAPY
DOI	10.1002/smll.201906870
英文摘要	The market of available contrast agents for clinical magnetic resonance imaging (MRI) has been dominated by gadolinium (Gd) chelates based T-1 contrast agents for decades. However, there are growing concerns about their safety because they are retained in the body and are nephrotoxic, which necessitated a warning by the U.S. Food and Drug Administration against the use of such contrast agents. To ameliorate these problems, it is necessary to improve the MRI efficiency of such contrast agents to allow the administration of much reduced dosages. In this study, a ten-gram-scale facile method is developed to synthesize organogadolinium complex nanoparticles (i.e., reductive bovine serum albumin stabilized Gd-salicylate nanoparticles, GdSalNPs-rBSA) with high r(1) value of 19.51 mm(-1) s(-1) and very low r(2)/r(1) ratio of 1.21 (B-0 = 1.5 T) for high-contrast T-1-weighted MRI of tumors. The GdSalNPs-rBSA nanoparticles possess more advantages including low synthesis cost (approximate to 0.54 USD per g), long in vivo circulation time (t(1/2) = 6.13 h), almost no Gd3+ release, and excellent biosafety. Moreover, the GdSalNPs-rBSA nanoparticles demonstrate excellent in vivo MRI contrast enhancement (signal-to-noise ratio (Delta SNR) approximate to 220%) for tumor diagnosis.
学科主题	Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
内容类型	期刊论文
源URL	[http://ir.nimte.ac.cn/handle/174433/19956]
专题	2020专题
作者单位	1.Shen, ZY (corresponding author), Southern Med Univ, Sch Biomed Engn, Biomat Res Ctr, Guangdong Prov Key Lab Construct & Detect Tissue, 1023 Shatai South Rd, Guangzhou 510515, Guangdong, Peoples R China. 2.Qiu, XZ 3.Wu, AG (corresponding author), Chinese Acad Sci, CAS Key Lab Magnet Mat & Devices, Key Lab Addit Mfg Mat Zhejiang Prov, Cixi Inst Biomed Engn,Ningbo Inst Mat Technol & E, 1219 Zhongguan West Rd, Ningbo 315201, Zhejiang, Peoples R China.
推荐引用方式 GB/T 7714	Wei, Zhenni,Jiang, Zhenqi,Pan, Chunshu,et al. Ten-Gram-Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis[J]. SMALL,2020,16(11).
APA	Wei, Zhenni.,Jiang, Zhenqi.,Pan, Chunshu.,Xia, Jianbi.,Xu, Kaiwei.,...&Shen, Zheyu.(2020).Ten-Gram-Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis.SMALL,16(11).
MLA	Wei, Zhenni,et al."Ten-Gram-Scale Facile Synthesis of Organogadolinium Complex Nanoparticles for Tumor Diagnosis".SMALL 16.11(2020).