Could Environment Affect the Mutation of H1N1 Influenza Virus?

doi:10.3390/ijerph17093092

	Could Environment Affect the Mutation of H1N1 Influenza Virus?
	Jiang, Dong 1,3; Wang, Qian 1,3; Bai, Zhihua 1,4; Qi, Heyuan 4; Ma, Juncai 4; Liu, Wenjun 1,2,4,5; Ding, Fangyu 3,4; Li, Jing 1,4
刊名	INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
	2020-05-01
卷号	17 期号:9 页码:9
关键词	H1N1 influenza virus mutation environment factors
DOI	10.3390/ijerph17093092
通讯作者	Ding, Fangyu(dingfy.17b@igsnrr.ac.cn) ; Li, Jing(lj418@163.com)
英文摘要	H1N1 subtype influenza A viruses are the most common type of influenza A virus to infect humans. The two major outbreaks of the virus in 1918 and 2009 had a great impact both on human health and social development. Though data on their complete genome sequences have recently been obtained, the evolution and mutation of A/H1N1 viruses remain unknown to this day. Among many drivers, the impact of environmental factors on mutation is a novel hypothesis worth studying. Here, a geographically disaggregated method was used to explore the relationship between environmental factors and mutation of A/H1N1 viruses from 2000-2019. All of the 11,721 geo-located cases were examined and the data was analysed of six environmental elements according to the time and location (latitude and longitude) of those cases. The main mutation value was obtained by comparing the sequence of the influenza virus strain with the earliest reported sequence. It was found that environmental factors systematically affect the mutation of A/H1N1 viruses. Minimum temperature displayed a nonlinear, rising association with mutation, with a maximum similar to 15 degrees C. The effects of precipitation and social development index (nighttime light) were more complex, while population density was linearly and positively correlated with mutation of A/H1N1 viruses. Our results provide novel insight into understanding the complex relationships between mutation of A/H1N1 viruses and environmental factors.
资助项目	Mega-Project of Guangxi Natural Science Foundation[2015GXNSFEA139002] ; National Natural Science Foundation of China[31970153] ; National Natural Science Foundation of China[31630079] ; National Key R&D Program of China[2016YFD0500206] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29010000] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA19040305] ; Youth Innovation Promotion Association of CAS[2019091]
WOS关键词	CLIMATE-CHANGE ; EVOLUTION ; INFECTION ; DIVERSITY ; TRENDS
WOS研究方向	Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
语种	英语
出版者	MDPI
WOS记录号	WOS:000535745400116
资助机构	Mega-Project of Guangxi Natural Science Foundation ; National Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences ; Youth Innovation Promotion Association of CAS
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/159564]
专题	中国科学院地理科学与资源研究所
通讯作者	Ding, Fangyu; Li, Jing
作者单位	1.Univ Chinese Acad Sci, Savaid Med Sch, Beijing 100049, Peoples R China 2.Guangxi Univ, Coll Anim Sci & Vet Med, Lab Anim Infect Dis, Nanning 530004, Guangxi, Peoples R China 3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China 4.Chinese Acad Sci, Inst Microbiol, CAS Key Lab Pathogen Microbiol & Immunol, Beijing 100101, Peoples R China 5.Guangxi Univ, Coll Anim Sci & Vet Med, State Key Lab Conservat & Utilizat Subtrop Agrobi, Nanning 530004, Guangxi, Peoples R China
推荐引用方式 GB/T 7714	Jiang, Dong,Wang, Qian,Bai, Zhihua,et al. Could Environment Affect the Mutation of H1N1 Influenza Virus?[J]. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,2020,17(9):9.
APA	Jiang, Dong.,Wang, Qian.,Bai, Zhihua.,Qi, Heyuan.,Ma, Juncai.,...&Li, Jing.(2020).Could Environment Affect the Mutation of H1N1 Influenza Virus?.INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH,17(9),9.
MLA	Jiang, Dong,et al."Could Environment Affect the Mutation of H1N1 Influenza Virus?".INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 17.9(2020):9.