Simultaneous analysis of typical halogenated endocrine disrupting chemicals and metal(loid)s in human hair

doi:10.1016/j.scitotenv.2020.137300

	Simultaneous analysis of typical halogenated endocrine disrupting chemicals and metal(loid)s in human hair
	Ren, Mengyuan 5,6; Jia, Xiaoqian 5,6; Shi, Jiazhang 7; Yan, Lailai 2; Li, Zewu 5,6; Lan, Changxin 5,6; Chen, Junxi 5,6; Li, Nan 5,6; Li, Kexin 3; Huang, Jing 1,7
刊名	SCIENCE OF THE TOTAL ENVIRONMENT
	2020-05-20
卷号	718 页码:10
关键词	Hair Simultaneous analysis Endocrine disrupting chemicals Metal(loid)s Exposome
ISSN号	0048-9697
DOI	10.1016/j.scitotenv.2020.137300
通讯作者	Li, Zhiwen(lizw@bjmu.edu.cn) ; Wang, Bin(binwangpku@foxmail.com)
英文摘要	Hair analysis has been an important approach in evaluating population exposure to various environmental fac-tors. To meet the requirements of human environmental epidemiology studies, we aimed to develop an efficient method for simultaneous analysis of various metal(loid)s and some typical environmental halogenated endo-crine disrupting chemicals (hEDCs) (i.e., polychlorinated biphenyls, polybrominated diphenyl ethers, and organ-ochlorine pesticides, as well as some of their hydroxyl substituted metabolites) in a single hair sample. The hair was washed successively with surfactant solutions, methanol solvent, and deionized water to remove impurities attached to the hair surface. Efficiency was comprehensively compared among various washing strategies. The hair sample was further pulverized into line powder with a median diameter (25th-75th percentile) of 8.6 (5.9-13.5) mu m. The hair organic components were extracted by acetonitrile solvent and compared with the microwave-assisted extraction method. The hEDCs in the supernatant acetonitrile phase were quantified by gas chromatography-mass spectrometry, and the metal(loid)s in the precipitate hair were further analyzed by inductively coupled plasma mass spectrometry. Our developed method was further applied to analyze the hair samples of 165 pregnant women. The results showed that particles attached to the surface of the hair could not be washed off completely. However, we proposed a protocol framework to wash hair with relatively high efficience, which includes warm water incubation, and use of surfactant and organic solvent. The recoveries of the concerned hEDCs and metal( loid)s were overall in the range of 80% to 120%. For the women population, the method can efficiently recognize the typical exposure characteristics of the concerned hEDCs and metal(loid)s. Our study significantly ameliorated the deficiencies of the traditional hair washing strategy and developed an efficient method for simultaneous analysis of various metal(loid)s and hEDCs in a single hair sample. This method will provide important support for population complex exposure analysis and facilitate environmental exposome studies. (C) 2020 Elsevier B.V. All rights reserved.
资助项目	National Natural Science Foundation of China[41771527] ; National Natural Science Foundation of China[81673177] ; National Natural Science Foundation of China[41830641]
WOS关键词	POLYCYCLIC AROMATIC-HYDROCARBONS ; NEURAL-TUBE DEFECTS ; RARE-EARTH-ELEMENTS ; POLYBROMINATED DIPHENYL ETHERS ; SOLID-PHASE MICROEXTRACTION ; ASSISTED SOLVENT-EXTRACTION ; MASS-SPECTROMETRY ; MATERNAL HAIR ; E-WASTE ; POLYCHLORINATED-BIPHENYLS
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER
WOS记录号	WOS:000526029000127
资助机构	National Natural Science Foundation of China
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/133815]
专题	中国科学院地理科学与资源研究所
通讯作者	Li, Zhiwen; Wang, Bin
作者单位	1.Peking Univ, Key Lab Mol Cardiovasc Sci, Minist Educ, Beijing, Peoples R China 2.Peking Univ, Sch Publ Hlth, Dept Laboratorial Sci & Technol, Beijing 100191, Peoples R China 3.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, Beijing 100101, Peoples R China 4.Peking Univ, Peoples Hosp, Reprod Med Ctr, Beijing 100044, Peoples R China 5.Peking Univ, Inst Reprod & Child Hlth, Beijing 100191, Peoples R China 6.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China 7.Peking Univ, Dept Occupat & Environm Hlth Sci, Sch Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式 GB/T 7714	Ren, Mengyuan,Jia, Xiaoqian,Shi, Jiazhang,et al. Simultaneous analysis of typical halogenated endocrine disrupting chemicals and metal(loid)s in human hair[J]. SCIENCE OF THE TOTAL ENVIRONMENT,2020,718:10.
APA	Ren, Mengyuan.,Jia, Xiaoqian.,Shi, Jiazhang.,Yan, Lailai.,Li, Zewu.,...&Liu, Jianmeng.(2020).Simultaneous analysis of typical halogenated endocrine disrupting chemicals and metal(loid)s in human hair.SCIENCE OF THE TOTAL ENVIRONMENT,718,10.
MLA	Ren, Mengyuan,et al."Simultaneous analysis of typical halogenated endocrine disrupting chemicals and metal(loid)s in human hair".SCIENCE OF THE TOTAL ENVIRONMENT 718(2020):10.