Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China

doi:10.1016/j.envpol.2019.05.096

	Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China
	Pei, Lu 1,4; Zhao, Meiduo 1,4; Xu, Jing 1,4; Li, Ang 1,4; Luo, Kai 1,4; Li, Runkui 2,5; Yang, Mingan 3; Xu, Qun 1,4
刊名	ENVIRONMENTAL POLLUTION
	2019-09-01
卷号	252 页码:1019-1025
关键词	PM2.5 constituents Health effect Complement C3 Short-term exposure
ISSN号	0269-7491
DOI	10.1016/j.envpol.2019.05.096
通讯作者	Xu, Qun(xuqun@ibms.cams.cn)
英文摘要	Epidemiological studies have demonstrated association between the total mass of fine particulate matter (PM2.5) exposures and inflammation. There are few studies exploring the associations between PM2.5 constituents and the biomarkers of inflammation in older adults and the underlying biological mechanisms are not exact. In this study, we examined the associations between PM2.5 and its constituents (organic carbon (OC), elemental carbon (EC), total carbon (TC), polycyclic aromatic hydrocarbons (PAH5) and complement three factor (C3), an important biomarker of inflammation in a repeated panel of 175 older adults in Beijing, China. We have constructed three different linear mixed effect models (single-pollutant model, constituent-PM2.5 joint model, and constituent-residual model) to evaluate the association of PM2.5 and its constituents and complement C3, controlling for concentration of high sensitive C-reactive protein (hs-CRP), day of week, mean temperature, relative humidity, location and potential individual confounders. We found robust positive associations of OC, EC, TC, PAHs and PM2.5 mass concentration with complement C3 at different lag patterns. The cumulative effects of pollutants increased across average of 2-5 days. Individuals aged 65 and above, or with diabetes, or BMI >= 30, or with no-cardiopathy, or with hypertension also exhibited positive associations between PM2.5 and complement C3. The results revealed that short-term exposure to PM2.5 and its constituents could result in a significant increase in serum level of complement C3. These findings suggested a possible involvement of complement C3 in the effect of PM2.5 on inflammatory reaction. (C) 2019 Published by Elsevier Ltd.
资助项目	China Medical Board[15-230] ; National Key Research and Development Program of China[2017YFB0503605] ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences[2017-I2M-1-009] ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences[Y88Q0300YD] ; National Natural Science Foundation of China[41771435] ; China Scholarship Council[201704910297]
WOS关键词	AIR-POLLUTION ; INSULIN-RESISTANCE ; INFLAMMATORY DISEASES ; HOSPITAL ADMISSIONS ; METABOLIC SYNDROME ; BLOOD-PRESSURE ; EXPOSURE ; MARKERS ; ACTIVATION ; SYSTEM
WOS研究方向	Environmental Sciences & Ecology
语种	英语
出版者	ELSEVIER SCI LTD
WOS记录号	WOS:000483405400010
资助机构	China Medical Board ; National Key Research and Development Program of China ; Chinese Academy of Medical Science Innovation Fund for Medical Sciences ; Program of Science and Technology Service Network Initiative (STS) of Chinese Academy of Sciences ; National Natural Science Foundation of China ; China Scholarship Council
内容类型	期刊论文
源URL	[http://ir.igsnrr.ac.cn/handle/311030/69749]
专题	中国科学院地理科学与资源研究所
通讯作者	Xu, Qun
作者单位	1.Chinese Acad Med Sci, Sch Basic Med, Dept Epidemiol & Biostat, Inst Basic Med Sci,Peking Union Med Coll, Beijing 100005, Peoples R China 2.Chinese Acad Sci, Inst Geog Sci & Nat Resources Res, State Key Lab Resources & Environm Informat Syst, Beijing 100101, Peoples R China 3.San Diego State Univ, Grad Sch Publ Hlth, Div Biostat & Epidemiol, San Diego, CA 92182 USA 4.Chinese Acad Med Sci, Peking Union Med Coll, Ctr Environm & Hlth Sci, Beijing 100005, Peoples R China 5.Univ Chinese Acad Sci, Coll Resources & Environm, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Pei, Lu,Zhao, Meiduo,Xu, Jing,et al. Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China[J]. ENVIRONMENTAL POLLUTION,2019,252:1019-1025.
APA	Pei, Lu.,Zhao, Meiduo.,Xu, Jing.,Li, Ang.,Luo, Kai.,...&Xu, Qun.(2019).Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China.ENVIRONMENTAL POLLUTION,252,1019-1025.
MLA	Pei, Lu,et al."Associations of ambient fine particulate matter and its constituents with serum complement C3 in a panel study of older adults in China".ENVIRONMENTAL POLLUTION 252(2019):1019-1025.