Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity

doi:10.3390/polym12112460

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室

	Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity
	Mi, Yingqi 1,2,3; Tan, Wenqiang 2,3; Zhang, Jingjing 2,3; Guo, Zhanyong 1,2,3
刊名	POLYMERS
	2020-11-01
卷号	12 期号:11 页码:16
关键词	antioxidant activity hydroxypropyltrimethyl ammonium chloride chitosan organic acid salt ion exchange
DOI	10.3390/polym12112460
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	A novel and green method for the preparation of chitosan derivatives bearing organic acids was reported in this paper. In order to improve the antioxidant activity of chitosan, eight different hydroxypropyltrimethyl ammonium chitosan derivatives were successfully designed and synthesized via introducing of organic acids onto chitosan by mild and non-toxic ion exchange. The data of Fourier Transform Infrared (FTIR), C-13 Nuclear Magnetic Resonance (NMR), H-1 NMR, and elemental analysis for chitosan derivatives indicated the successful conjugation of organic acid salt with hydroxypropyltrimethyl ammonium chloride chitosan (HACC). Meanwhile, the antioxidant activity of the chitosan derivatives was evaluated in vitro. The results indicated that the chitosan derivatives possessed dramatic enhancements in DPPH-radical scavenging activity, superoxide-radical scavenging activity, hydroxyl radical scavenging ability, and reducing power. Furthermore, the cytotoxicity of the synthesized compounds was investigated in vitro on L929 cells and showed low cytotoxicity. Thus, the enhanced antioxidant property of all novel chitosan products might be a great advantage, while applied in a wide range of applications in the form of antioxidant in biomedical, food, and cosmetic industry.
资助项目	National Key R&D Program of China[2019YFD0900705] ; Natural Science Foundation of Shandong Province of China[ZR2019BD064] ; Natural Science Foundation of Shandong Province of China[ZR2017BD015] ; Youth Innovation Promotion Association CAS[2020219] ; National Natural Science Foundation of China[41576156] ; Natural Science Foundation of Shandong Province Science and Technology Development Plan[2019GHY112010]
WOS关键词	CHLORIDE CHITOSAN ; IN-VITRO ; DERIVATIVES
WOS研究方向	Polymer Science
语种	英语
WOS记录号	WOS:000593845900001
资助机构	National Key R&D Program of China ; Natural Science Foundation of Shandong Province of China ; Youth Innovation Promotion Association CAS ; National Natural Science Foundation of China ; Natural Science Foundation of Shandong Province Science and Technology Development Plan
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/28302]
专题	海岸带生物学与生物资源利用重点实验室烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Mi, Yingqi,Tan, Wenqiang,Zhang, Jingjing,et al. Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity[J]. POLYMERS,2020,12(11):16.
APA	Mi, Yingqi,Tan, Wenqiang,Zhang, Jingjing,&Guo, Zhanyong.(2020).Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity.POLYMERS,12(11),16.
MLA	Mi, Yingqi,et al."Modification of Hydroxypropyltrimethyl Ammonium Chitosan with Organic Acid: Synthesis, Characterization, and Antioxidant Activity".POLYMERS 12.11(2020):16.