Genetic Adaptations of an Island Pit-Viper to a Unique Sedentary Life with Extreme Seasonal Food Availability

doi:10.1534/g3.120.401101

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	Genetic Adaptations of an Island Pit-Viper to a Unique Sedentary Life with Extreme Seasonal Food Availability
	Lu, Bin 6; Wang, Xiaoping 5; Fu, Jinzhong 4; Shi, Jingsong 1,3; Wu, Yayong 2,6; Qi, Yin 6
刊名	G3-GENES GENOMES GENETICS
	2020-05-01
卷号	10 期号:5 页码:1639-1646
关键词	Genetic adaptations transcriptome extreme sedentary life Gloydius shedaoensis
ISSN号	2160-1836
DOI	10.1534/g3.120.401101
英文摘要	The Shedao pit-viper (Gloydius shedaoensis) exhibits an extreme sedentary lifestyle. The island species exclusively feeds on migratory birds during migratory seasons and experiences prolonged hibernation and aestivation period each year (up to eight months). The sedentary strategy reduces energy expenditure, but may trigger a series of adverse effects and the snakes have likely evolved genetic modifications to alleviate these effects. To investigate the genetic adaptations, we sequenced and compared the transcriptomes of the Shedao pit-viper and its closest mainland relative, the black eyebrow pit-viper (G. intermedius). The Shedao pit-viper revealed a low rate of molecular evolution compared to its mainland relative, which is possibly associated with metabolic suppression. Signals of positive selection were detected in two genes related to antithrombin (SERPINC1) and muscle atrophy (AARS). Those genes exert significant functions in thrombosis, inhibiting oxidation and prolonged fasting. Convergent and parallel substitutions of amino acid with two other sedentary vertebrates, which often suggest adaptation, were found in a fatty acid beta-oxidation related gene (ACATA1) and a circadian link gene (KLF10), which regulate lipogenesis, gluconeogenesis, and glycolysis. Furthermore, a circadian clock gene (CRY2) exhibited two amino acid substitutions specific to the Shedao pit-viper and one variant was predicted to affect protein function. Modifications of these genes and their related functions may have contributed to the survival of this island snake species with a sedentary lifestyle and extreme seasonal food availability. Our study demonstrated several important clues for future research on physiological and other phenotypic adaptation.
资助项目	National Natural Science Foundation of China[31872233] ; National Natural Science Foundation of China[31401961] ; National Natural Science Foundation of China[31460559] ; Liaoning Snake Island Laotie Mountain National Nature Reserve[Y8Y3041] ; Sichuan Science and Technology Program[18YYJC0171]
WOS关键词	AMINO-ACID SUBSTITUTIONS ; TRANSFER-RNA SYNTHETASE ; PHYLOGENETIC ANALYSIS ; DIVERGENCE TIMES ; CONVERGENT ; EXPRESSION ; EVOLUTION ; CLOCK ; 8-HYDROXY-2-DEOXYGUANOSINE ; CRYPTOCHROME
WOS研究方向	Genetics & Heredity
语种	英语
出版者	GENETICS SOCIETY AMERICA
WOS记录号	WOS:000532223200019
内容类型	期刊论文
源URL	[http://119.78.100.205/handle/311034/17482]
专题	古脊椎动物与古人类研究所_图书馆1
通讯作者	Qi, Yin
作者单位	1.Chinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing 100044, Peoples R China 2.Yibin Univ, Coll Life Sci & Food Engn, Yibin 644007, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Guelph, Dept Integrat Biol, Guelph, ON N1G 2W1, Canada 5.Nat Conservat Snake Isl & Laotieshan Mt, Dalian 116041, Peoples R China 6.Chinese Acad Sci, Chengdu Inst Biol, 9,Seciton 4,Ren Min Nan Rd, Chengdu 610041, Sichuan, Peoples R China
推荐引用方式 GB/T 7714	Lu, Bin,Wang, Xiaoping,Fu, Jinzhong,et al. Genetic Adaptations of an Island Pit-Viper to a Unique Sedentary Life with Extreme Seasonal Food Availability[J]. G3-GENES GENOMES GENETICS,2020,10(5):1639-1646.
APA	Lu, Bin,Wang, Xiaoping,Fu, Jinzhong,Shi, Jingsong,Wu, Yayong,&Qi, Yin.(2020).Genetic Adaptations of an Island Pit-Viper to a Unique Sedentary Life with Extreme Seasonal Food Availability.G3-GENES GENOMES GENETICS,10(5),1639-1646.
MLA	Lu, Bin,et al."Genetic Adaptations of an Island Pit-Viper to a Unique Sedentary Life with Extreme Seasonal Food Availability".G3-GENES GENOMES GENETICS 10.5(2020):1639-1646.