Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities

doi:10.1016/j.carbpol.2020.115903

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物资源高效利用研究与发展中心

	Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities
	Zhang, JJ ; Sun, XQ ; Chen, Y ; Mi, YQ ; Tan, WQ ; Miao, Q ; Li, Q ; Dong, F ; Guo, ZY
刊名	CARBOHYDRATE POLYMERS
	2020-04-15
卷号	234 页码:115903
关键词	Antifungal activity Antioxidant activity Chitosan oligosaccharide derivatives Cytotoxicity Urea groups
ISSN号	0144-8617
DOI	10.1016/j.carbpol.2020.115903
产权排序	[Zhang, Jingjing ; Sun, Xueqi ; Chen, Yuan ; Mi, Yingqi ; Tan, Wenqiang ; Miao, Qin ; Li, Qing ; Dong, Fang ; Guo, Zhanyong] Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China ; [Zhang, Jingjing ; Sun, Xueqi ; Chen, Yuan ; Mi, Yingqi ; Tan, Wenqiang ; Miao, Qin ; Li, Qing ; Dong, Fang ; Guo, Zhanyong] Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China ; [Zhang, Jingjing ; Sun, Xueqi ; Chen, Yuan ; Mi, Yingqi ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
文献子类	Article
英文摘要	In this study, 2-urea-chitosan oligosaccharide derivatives (2-urea-COS derivatives) and 2,6-diurea-chitosan oligosaccharide derivatives (2,6-diurea-COS derivatives) were successfully designed and synthesized via intermediate 2-methoxyformylated chitosan oligosaccharide. All samples were characterized and compared based on FT-IR, H-1 NMR spectroscopy, and elemental analysis. The antifungal effects of COS derivatives were tested against Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, and Botrytis cinereal. Their antioxidant properties, including superoxide radicals' scavenging activity, hydroxyl radicals' scavenging activity, and DPPH radicals' scavenging activity were also explored within different concentrations. COS derivatives bearing urea groups showed improved bioactivity compared with pristine COS and 2,6-diurea-COS derivatives had a higher biological activity than 2-urea-COS derivatives in tested concentrations. Additionally, L929 cells were used to carry out cytotoxicity test of COS and COS derivatives by CCK-8 assay. The results indicated that some of samples showed low cytotoxicity. These findings offered a suggestion that COS derivatives bearing urea groups are promising biological materials.
WOS关键词	CHITOSAN DERIVATIVES ; IN-VITRO
WOS研究方向	Chemistry, Applied ; Chemistry, Organic ; Polymer Science
语种	英语
WOS记录号	WOS:000513917300027
资助机构	National Key R&D Program of China [2019YFD0900705] ; Natural Science Foundation of Shandong Province of ChinaNatural Science Foundation of Shandong Province [ZR2019BD064, ZR2017BD015] ; Youth Innovation Promotion Association CAS [2020219] ; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [41576156] ; Natural Science Foundation of Shandong Province Science and Technology Development Plan [2019GHY112010]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24737]
专题	海岸带生物资源高效利用研究与发展中心烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Chinese Acad Sci, Key Lab Coastal Biol & Bioresource Utilizat, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 2.Chinese Acad Sci, Ctr Ocean Mega Sci, 7 Nanhai Rd, Qingdao 266071, Peoples R China; 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, JJ,Sun, XQ,Chen, Y,et al. Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities[J]. CARBOHYDRATE POLYMERS,2020,234:115903.
APA	Zhang, JJ.,Sun, XQ.,Chen, Y.,Mi, YQ.,Tan, WQ.,...&Guo, ZY.(2020).Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities.CARBOHYDRATE POLYMERS,234,115903.
MLA	Zhang, JJ,et al."Preparation of 2,6-diurea-chitosan oligosaccharide derivatives for efficient antifungal and antioxidant activities".CARBOHYDRATE POLYMERS 234(2020):115903.