Synthesis and Characterization of Inulin Derivatives Bearing Urea Groups with Promising Antifungal Activity

doi:10.1002/star.201800058

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物资源高效利用研究与发展中心

	Synthesis and Characterization of Inulin Derivatives Bearing Urea Groups with Promising Antifungal Activity
	Zhang, Jingjing ; Tan, Wenqiang ; Mi, Yingqi ; Luan, Fang ; Wei, Lijie ; Li, Qing ; Dong, Fang ; Guo, Zhanyong
刊名	STARCH-STARKE
	2019-01
卷号	71 期号:1-2 页码:1800058-
关键词	antifungal activity inulin derivatives structure characteristics synthesis urea groups
ISSN号	0038-9056
DOI	10.1002/star.201800058
产权排序	[Zhang, Jingjing ; Tan, Wenqiang ; Mi, Yingqi ; Luan, Fang ; Wei, Lijie ; Li, Qing ; Dong, Fang ; Guo, Zhanyong] Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China ; [Zhang, Jingjing ; Tan, Wenqiang ; Mi, Yingqi ; Luan, Fang ; Wei, Lijie ; Guo, Zhanyong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
文献子类	Article
英文摘要	The toxicity concerns associated with chemical fungicides currently on the market have resulted in an increased demand for alternative ecofriendly fungicides. As a biodegradable and biocompatible dietary fiber, inulin shows potential as such a compound, given its lack of toxicity. In the current study, seven novel inulin derivatives with promising antifungal activity (BUCAIL, 2CBUCAIL, 3CBUCAIL, 4CBUCAIL, 3,4CBUCAIL, 2FBUCAIL, and 2BBUCAIL) are synthesized via condensation reactions of chloroacetyl inulin (CAIL) with urea groups bearing 4-amino-pyridine. Their structures are confirmed using FT-IR, H-1 NMR, C-13 NMR, and elemental analysis. Their antifungal activity against three kinds of phytopathogen (Fusarium oxysporum f. sp. niveum, Phomopsis asparagus, and Fusarium oxysporum f. sp. cucumebrium Owen) is evaluated using the mycelial growth rate in vitro at concentrations of 0.10, 0.25, 0.50, 0.75, and 1.0 mg mL(-1). Results reveal that all seven inulin derivatives show improved antifungal properties compared with unmodified inulin, and two obvious inhibition rules are found: 3,4CBUCAIL > 4CBUCAIL > 3CBUCAIL > 2CBUCAIL > BUCAIL > CAIL > inulin and 2FBUCAIL > 2CBUCAIL > 2BBUCAIL > BUCAIL > CAIL > inulin. Thus, the introduction of urea groups into inulin derivatives could be key to increasing the antifungal activity of such compounds.
WOS关键词	ANTIBACTERIAL ACTIVITY ; ANTIOXIDANT ; COMPLEXES ; ESTERS
WOS研究方向	Food Science & Technology
语种	英语
WOS记录号	WOS:000454708500012
资助机构	National Natural Science Foundation of China [41576156] ; Shandong Province Science and Technology Development Plan [2015GSF121045] ; Yantai Science and Technology Development Plan [2015ZH078] ; Technology Research Funds Projects of Ocean [2015418022-3]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24608]
专题	海岸带生物资源高效利用研究与发展中心烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室烟台海岸带研究所_污染过程与控制实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Peoples R China; 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式 GB/T 7714	Zhang, Jingjing,Tan, Wenqiang,Mi, Yingqi,et al. Synthesis and Characterization of Inulin Derivatives Bearing Urea Groups with Promising Antifungal Activity[J]. STARCH-STARKE,2019,71(1-2):1800058-.
APA	Zhang, Jingjing.,Tan, Wenqiang.,Mi, Yingqi.,Luan, Fang.,Wei, Lijie.,...&Guo, Zhanyong.(2019).Synthesis and Characterization of Inulin Derivatives Bearing Urea Groups with Promising Antifungal Activity.STARCH-STARKE,71(1-2),1800058-.
MLA	Zhang, Jingjing,et al."Synthesis and Characterization of Inulin Derivatives Bearing Urea Groups with Promising Antifungal Activity".STARCH-STARKE 71.1-2(2019):1800058-.