Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment

doi:10.1016/j.ijbiomac.2020.08.250

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment
	Li, Qing 1,2; Mi, Yingqi 1,3; Tan, Wenqiang 1,2; Guo, Zhanyong 1,2
刊名	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
	2020-12-01
卷号	164 页码:4279-4288
关键词	Chitosan Free radical-scavenging Chemical modification
ISSN号	0141-8130
DOI	10.1016/j.ijbiomac.2020.08.250
通讯作者	Guo, Zhanyong(zhanyongguo@hotmail.com)
英文摘要	Chitosan is an abundant and renewable polysaccharide, and chemical modification can be used to enhance the biological properties of chitosan. In this study, monophenol and ortho-diphenol were introduced to chitosan through chemical modification to get chitosan derivatives owned high antioxidant activity. Their free radical-scavenging activity against three free radicals and reduction ability was tested. Based on the four antioxidant assay, the antioxidant ability of the synthesized chitosan derivatives exhibited a remarkable improvement over chitosan. The IC50 of inhibition of DPPH, hydroxyl ((OH)-O-center dot), and superoxide (O2 center dot-) radical-scavenging was 41-172, 10-89, and 14-38 mu g/mL, respectively. Meanwhile, ortho-diphenol was more efficient group than monophenol on the improvement of antioxidant ability of chitosan derivatives. The possible free radical-scavenging mechanism, including the number of the hydroxyl groups and the presence ortho-dihydroxy substitution for the antioxidant ability were discussed. In vitro studies demonstrated that the constructed chitosan derivatives have good biocompatibility, and good antioxidant capacity to reduce oxidative stress. Functionalization of chitosan with phenolic group allows the possible applications on the therapy of oxidative-related diseases. (C) 2020 Elsevier B.V. All rights reserved.
资助项目	Key Technology Research and Development Program of Shandong[2019GHY112010] ; Natural Science Foundation of Shandong[ZR2019BD064] ; National Key Research & Development Program of China[2019YFD0900705]
WOS关键词	ANTIOXIDANT ACTIVITY ; INULIN DERIVATIVES ; OXIDATIVE STRESS ; FLAVONOIDS ; POLYPHENOLS ; MECHANISMS ; AGENTS ; DPPH ; DFT
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
语种	英语
WOS记录号	WOS:000588093700407
资助机构	Key Technology Research and Development Program of Shandong ; Natural Science Foundation of Shandong ; National Key Research & Development Program of China
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/27513]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室海岸带生物资源高效利用研究与发展中心
通讯作者	Guo, Zhanyong
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, Key Lab Coastal Biol & Bioresource Utilizat, Yantai 264003, Shandong, Peoples R China 2.Chinese Acad Sci, Ctr Ocean Megasci, 7 Nanhai Rd, Qingdao 266071, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100039, Peoples R China
推荐引用方式 GB/T 7714	Li, Qing,Mi, Yingqi,Tan, Wenqiang,et al. Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2020,164:4279-4288.
APA	Li, Qing,Mi, Yingqi,Tan, Wenqiang,&Guo, Zhanyong.(2020).Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,164,4279-4288.
MLA	Li, Qing,et al."Highly efficient free radical-scavenging property of phenolic-functionalized chitosan derivatives: Chemicalmodification and activity assessment".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 164(2020):4279-4288.