Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity

doi:10.1155/2019/4735040

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 海岸带生物学与生物资源利用重点实验室 > 海岸带生物学与生物资源利用所重点实验室

	Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity
	Wang, L ; Zhu, LM ; Qin, S
刊名	JOURNAL OF IMMUNOLOGY RESEARCH
	2019-10-03
卷号	2019 页码:4735040
关键词	REGULATORY T-CELLS DENDRITIC CELLS INTRAEPITHELIAL LYMPHOCYTES PEYERS-PATCHES PROTECTIVE IGA T(H)17 CELLS INDUCTION PROMOTES BACTERIA TH17
ISSN号	2314-8861
DOI	10.1155/2019/4735040
产权排序	[Wang, Li] Infect Dis Hosp Yantai, Hepatol Dept, 62 Huanshan Rd, Yantai 264001, Peoples R China ; [Zhu, Limeng] Univ Chinese Acad Sci, Inst Proc Engn, 1 North 2nd St, Beijing 100049, Peoples R China ; [Qin, Song] Chinese Acad Sci, Yantai Inst Costal Zone Res, 17 Chunhui Rd, Yantai 264003, Peoples R China
文献子类	Review
英文摘要	The mammalian intestine harbors a remarkable number of microbes and their components and metabolites, which are fundamental for the instigation and development of the host immune system. The intestinal innate and adaptive immunity coordinate and interact with the symbionts contributing to the intestinal homeostasis through establishment of a mutually beneficial relationship by tolerating to symbiotic microbiota and retaining the ability to exert proinflammatory response towards invasive pathogens. Imbalance between the intestinal immune system and commensal organisms disrupts the intestinal microbiological homeostasis, leading to microbiota dysbiosis, compromised integrity of the intestinal barrier, and proinflammatory immune responses towards symbionts. This, in turn, exacerbates the degree of the imbalance. Intestinal adaptive immunity plays a critical role in maintaining immune tolerance towards symbionts and the integrity of intestinal barrier, while the innate immune system regulates the adaptive immune responses to intestinal commensal bacteria. In this review, we will summarize recent findings on the effects and mechanisms of gut microbiota on intestinal adaptive immunity and the plasticity of several immune cells under diverse microenvironmental settings.
WOS关键词	REGULATORY T-CELLS ; DENDRITIC CELLS ; INTRAEPITHELIAL LYMPHOCYTES ; PEYERS-PATCHES ; PROTECTIVE IGA ; T(H)17 CELLS ; INDUCTION ; PROMOTES ; BACTERIA ; TH17
WOS研究方向	Immunology
语种	英语
WOS记录号	WOS:000491939000001
资助机构	National Key Research and Development Program of China [2018YFD091102]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24835]
专题	烟台海岸带研究所_海岸带生物学与生物资源利用所重点实验室
作者单位	1.Infect Dis Hosp Yantai, Hepatol Dept, 62 Huanshan Rd, Yantai 264001, Peoples R China; 2.Univ Chinese Acad Sci, Inst Proc Engn, 1 North 2nd St, Beijing 100049, Peoples R China; 3.Chinese Acad Sci, Yantai Inst Costal Zone Res, 17 Chunhui Rd, Yantai 264003, Peoples R China
推荐引用方式 GB/T 7714	Wang, L,Zhu, LM,Qin, S. Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity[J]. JOURNAL OF IMMUNOLOGY RESEARCH,2019,2019:4735040.
APA	Wang, L,Zhu, LM,&Qin, S.(2019).Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity.JOURNAL OF IMMUNOLOGY RESEARCH,2019,4735040.
MLA	Wang, L,et al."Gut Microbiota Modulation on Intestinal Mucosal Adaptive Immunity".JOURNAL OF IMMUNOLOGY RESEARCH 2019(2019):4735040.