Gold nanorods functionalized by a glutathione response near- infrared fluorescent probe as a promising nanoplatform for fluorescence imaging guided precision therapy

doi:10.1039/c9nr02296a

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 山东省海岸带环境工程技术研究中心

	Gold nanorods functionalized by a glutathione response near- infrared fluorescent probe as a promising nanoplatform for fluorescence imaging guided precision therapy
	Huang, Y ; Liu, QL ; Wang, YQ ; He, N ; Zhao, RF ; Choo, J ; Chen, LX
刊名	NANOSCALE
	2019-07-07
卷号	11 期号:25 页码:12220-12229
关键词	PHOTOTHERMAL THERAPY THERANOSTIC AGENT IN-VITRO CANCER NANOPARTICLES TUMORS DAMAGE STRESS FILTER
ISSN号	2040-3364
DOI	10.1039/c9nr02296a
产权排序	[Huang, Yan ; Wang, Yunqing ; He, Na ; Zhao, Rongfang ; Chen, Lingxin] Chinese Acad Sci, CAS Key Lab Coastal Environm Processes & Ecol Rem, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China ; [Liu, Qingluan] China Med Univ, Div Clin Med 3, Shenyang 110122, Liaoning, Peoples R China ; [Choo, Jaebum] Chung Ang Univ, Dept Chem, Seoul 06974, South Korea ; [Chen, Lingxin] Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China ; [Chen, Lingxin] Qufu Normal Univ, Key Lab Life Organ Anal, Inst Anticancer Agents Dev & Theranost Applicat, Qufu 273165, Peoples R China ; [Chen, Lingxin] Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Dept Chem & Chem Engn, Qufu 273165, Peoples R China ; [Chen, Lingxin] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China
文献子类	Article
英文摘要	Theranostics nanoplatforms offer opportunities for imaging-guided precision therapy and hold great potential for clinical applications. In most reported works, the imaging unit has a lack of site selectivity, and is always kept in the on modality regardless of whether it is in normal tissues or tumor sites, increasing the risk of unsafe treatment. Herein, we designed a near-infrared (NIR) fluorescence-guided theranostics nanoplatform by integrating the functions of tumor-response and photodynamic therapy (PDT)/photothermal therapy (PTT). A novel NIR fluorescent dye, CyPT, with excellent optical and PDT/PTT properties, was synthesized and linked onto the gold nanorods (AuNRs) to form CyPT-AuNRs nanohybrids via a sulfur-sulfur bond that can be broken by glutathione (GSH) with high selectivity and sensitivity. In normal cells where the concentration of GSH is low, the fluorescence of CyPT is quenched by the AuNRs. By contrast, the high level of GSH in tumor cells leads to the breaking of the sulfur-sulfur bond, resulting in the release of CyPT and the accomplishment of a off-on fluorescence response. Followed by precise NIR tumor-imaging diagnosis, the PDT and PTT treatment which rely on the released CyPT and AuNRs, respectively, can be effectively performed. The CyPT-AuNRs nanoplatform has been successfully applied to the treatment of tumor xenograft models and no distinct damage has been observed in the nearby normal tissues. This versatile nanoplatform has potential for use in targeted tumor imaging and precision therapy.
WOS关键词	PHOTOTHERMAL THERAPY ; THERANOSTIC AGENT ; IN-VITRO ; CANCER ; NANOPARTICLES ; TUMORS ; DAMAGE ; STRESS ; FILTER
WOS研究方向	Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
语种	英语
WOS记录号	WOS:000475468100017
资助机构	National Nature Science Foundation of ChinaNational Natural Science Foundation of China [21575159, 81573393] ; program of Youth Innovation Promotion Association, CAS [2017256] ; Instrument Developing Project of the Chinese Academy of Sciences [YZ201662] ; National Research Foundation of KoreaNational Research Foundation of Korea [2017M3D1A1039287, 2018M3A7B4071203]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24900]
专题	烟台海岸带研究所_山东省海岸带环境工程技术研究中心烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Chung Ang Univ, Dept Chem, Seoul 06974, South Korea; 2.Pilot Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China; 3.Qufu Normal Univ, Key Lab Life Organ Anal, Inst Anticancer Agents Dev & Theranost Applicat, Qufu 273165, Peoples R China; 4.Qufu Normal Univ, Key Lab Pharmaceut Intermediates & Anal Nat Med, Dept Chem & Chem Engn, Qufu 273165, Peoples R China; 5.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Shandong, Peoples R China 6.Chinese Acad Sci, CAS Key Lab Coastal Environm Processes & Ecol Rem, Res Ctr Coastal Environm Engn & Technol, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China; 7.China Med Univ, Div Clin Med 3, Shenyang 110122, Liaoning, Peoples R China;
推荐引用方式 GB/T 7714	Huang, Y,Liu, QL,Wang, YQ,et al. Gold nanorods functionalized by a glutathione response near- infrared fluorescent probe as a promising nanoplatform for fluorescence imaging guided precision therapy[J]. NANOSCALE,2019,11(25):12220-12229.
APA	Huang, Y.,Liu, QL.,Wang, YQ.,He, N.,Zhao, RF.,...&Chen, LX.(2019).Gold nanorods functionalized by a glutathione response near- infrared fluorescent probe as a promising nanoplatform for fluorescence imaging guided precision therapy.NANOSCALE,11(25),12220-12229.
MLA	Huang, Y,et al."Gold nanorods functionalized by a glutathione response near- infrared fluorescent probe as a promising nanoplatform for fluorescence imaging guided precision therapy".NANOSCALE 11.25(2019):12220-12229.