Gold Nanorod Array-Bridged Internal-Standard SERS Tags: From Ultrasensitivity to Multifunctionality

doi:10.1021/acsami.9b18292

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 山东省海岸带环境工程技术研究中心

	Gold Nanorod Array-Bridged Internal-Standard SERS Tags: From Ultrasensitivity to Multifunctionality
	Mei, RC ; Wang, YQ ; Yu, Q ; Yin, YC ; Zhao, RF ; Chen, LX
刊名	ACS APPLIED MATERIALS & INTERFACES
	2020-01-15
卷号	12 期号:2 页码:2059-2066
关键词	SERS gold nanorod silver nanoparticle bimetallic internal standard
ISSN号	1944-8244
DOI	10.1021/acsami.9b18292
产权排序	[Mei, Rongchao ; Wang, Yunqing ; Yu, Qian ; Zhao, Rongfang ; Chen, Lingxin] Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China ; [Yin, Yingchao] Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Yantai 264005, Peoples R China ; [Chen, Lingxin] Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China ; [Chen, Lingxin] Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
文献子类	Article
英文摘要	Bimetallic gold core-silver shell (Au@Ag) surface-enhanced Raman scattering (SERS) tags draw broad interest in the fields of biological and environmental analysis. In reported tags, silver coating tended to smooth the surface and merge the original hotspot of Au cores, which was disadvantageous to signal enhancement from the aspect of surface topography. Herein, we developed gold nanorod (AuNR)-bridged AupAg SERS tags with uniform three-dimensional (3D) topography for the first time. This unique structure was achieved by selecting waxberry-like Au nanoparticles (NPs) as cores, which were capped by vertically oriented AuNR arrays. Upon selective surface blocking with thiol-ligands, Ag NPs were controlled to anisotropically grow on the tips of the AuNRs, producing high-density homo- (Ag-Ag) and hetero- (Au-Ag) hotspots in a single NP. The 3D hotspots rendered this NP extraordinary SERS enhancement ability (an analytical enhancement factor of 3.4 x 10(6)) 30 times higher than the counterpart with a smooth surface, realizing signal detection from a single NP. More importantly, multiplexing signals ("blank" or multiplex "internal standard") can be achieved by simply changing thiol-ligands, as exemplified in the synthesis of NPs with 8 signatures. Furthermore, the multifunctionality has been demonstrated in living cell/in vivo imaging, photothermal therapy, and SERS substrates for ratiometric quantitative analysis, relying on the inherent internal standard signal. The prepared Au@Ag NPs have great potential as standard tools in many SERS-related fields.
WOS关键词	ENHANCED RAMAN-SCATTERING ; SURFACE ; SHELL ; NANOPARTICLES ; NANOSTRUCTURES ; NANOSTARS ; NANOGAP ; POLYMER
WOS研究方向	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
语种	英语
WOS记录号	WOS:000508464500009
资助机构	National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81573393, 21976209] ; Science and Technology Development Plan of Shandong Province of China [2019GSF108047] ; Youth Innovation Promotion Association CAS [2017256] ; Instrument Developing Project of the Chinese Academy of Sciences [YZ201662] ; Taishan Scholar Project Special Funding [ts20190962]
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24768]
专题	烟台海岸带研究所_山东省海岸带环境工程技术研究中心烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室
作者单位	1.Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China; 2.Yantai Univ, Collaborat Innovat Ctr Adv Drug Delivery Syst & B, Sch Pharm, Key Lab Mol Pharmacol & Drug Evaluat,Minist Educ, Yantai 264005, Peoples R China; 3.Qufu Normal Univ, Coll Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China; 4.Chinese Acad Sci, Ctr Ocean Mega Sci, Qingdao 266071, Peoples R China
推荐引用方式 GB/T 7714	Mei, RC,Wang, YQ,Yu, Q,et al. Gold Nanorod Array-Bridged Internal-Standard SERS Tags: From Ultrasensitivity to Multifunctionality[J]. ACS APPLIED MATERIALS & INTERFACES,2020,12(2):2059-2066.
APA	Mei, RC,Wang, YQ,Yu, Q,Yin, YC,Zhao, RF,&Chen, LX.(2020).Gold Nanorod Array-Bridged Internal-Standard SERS Tags: From Ultrasensitivity to Multifunctionality.ACS APPLIED MATERIALS & INTERFACES,12(2),2059-2066.
MLA	Mei, RC,et al."Gold Nanorod Array-Bridged Internal-Standard SERS Tags: From Ultrasensitivity to Multifunctionality".ACS APPLIED MATERIALS & INTERFACES 12.2(2020):2059-2066.