As, Cd, and Pb relative bioavailability in contaminated soils: Coupling mouse bioassay with UBM assay

doi:10.1016/j.envint.2019.05.069

CORC > 烟台海岸带研究所 > 中国科学院烟台海岸带研究所 > 中科院海岸带环境过程与生态修复重点实验室

	As, Cd, and Pb relative bioavailability in contaminated soils: Coupling mouse bioassay with UBM assay
	Zhu X; Li MY; Chen XQ; Wang JY; Li LZ; Tu C; Luo YM; Li HB; Ma LQ
刊名	Environment International
	2019
卷号	130 页码:104875
关键词	Heavy metals Mouse model Bioavailability In vitro assay Bioaccessibility
ISSN号	0160-4120
DOI	10.1016/j.envint.2019.05.069
产权排序	[Zhu, Xia ; Li, Lian-Zhen ; Tu, Chen ; Luo, Yong-Ming] Chinese Acad Sci, Yantai Inst Coastal Zone Res, CAS Key Lab Coastal Environm Proc & Ecol Remediat, Yantai 264003, Peoples R China ; [Zhu, Xia ; Luo, Yong-Ming] Univ Chinese Acad Sci, Beijing 100049, Peoples R China ; [Li, Meng-Ya ; Chen, Xiao-Qiang ; Wang, Jue-Yang ; Li, Hong-Bo ; Ma, Lena Q.] Nanjing Univ, Sch Environm, State Key Lab Pollut Control & Resource Reuse, Nanjing 210023, Jiangsu, Peoples R China ; [Luo, Yong-Ming] Chinese Acad Sci, Inst Soil Sci, Key Lab Soil Environm & Pollut Remediat, Nanjing 210008, Jiangsu, Peoples R China ; [Ma, Lena Q.] Univ Florida, Soil & Water Sci Dept, Gainesville, FL 32611 USA
文献子类	Article
英文摘要	The robustness of in vitro bioaccessibility assays to predict oral relative bioavailability (RBA) of multiple metals in contaminated soils requires validation using additional soil samples. In this study, 11 contaminated soils from mining/smelting areas were analyzed for As-, Cd-, and Pb-RBA using a mouse bioassay and metal bioaccessibility via the UBM gastric phase assay. Metal-RBA varied considerably among soils, with As-RBA (2.5-23%, mean 12%) being generally lower than Cd-and Pb-RBA (3.4-88 and 3.3-59%, mean 42 and 28%), due to higher proportions of As in the residual fractions. Metal-RBA generally decreased with increasing metal concentrations probably due to reduced labile metal fractions. In addition, strong negative correlations were observed between total Fe with As-, Cd-, and Pb-RBA (R-2 = 0.46-0.77), suggesting the role of Fe in controlling metal-RBA in soils. Like RBA, metal bioaccessibility by the UBM assay also varied among samples. However, strong in vivo-in vitro correlations (IVIVCs) were observed between metal-RBA and bioaccessibility (R-2 = 0.52-0.81). Further, there were little differences when As-, Cd-, and Pb-IVIVCs established using soils from this study and soils pooled from literature were compared, suggesting the robustness of the UBM assay to predict metal-RBA in contaminated soils.
WOS关键词	IN-VITRO ASSAYS ; UNIFIED BARGE METHOD ; ARSENIC BIOAVAILABILITY ; PREDICTIVE CAPABILITIES ; BIOACCESSIBILITY ; LEAD ; VIVO ; CADMIUM ; VALIDATION ; SPECIATION
WOS研究方向	Environmental Sciences
语种	英语
WOS记录号	WOS:000477934800014
内容类型	期刊论文
源URL	[http://ir.yic.ac.cn/handle/133337/24141]
专题	烟台海岸带研究所_中科院海岸带环境过程与生态修复重点实验室烟台海岸带研究所_近岸生态与环境实验室
通讯作者	Luo YM; Li HB
推荐引用方式 GB/T 7714	Zhu X,Li MY,Chen XQ,et al. As, Cd, and Pb relative bioavailability in contaminated soils: Coupling mouse bioassay with UBM assay[J]. Environment International,2019,130:104875.
APA	Zhu X.,Li MY.,Chen XQ.,Wang JY.,Li LZ.,...&Ma LQ.(2019).As, Cd, and Pb relative bioavailability in contaminated soils: Coupling mouse bioassay with UBM assay.Environment International,130,104875.
MLA	Zhu X,et al."As, Cd, and Pb relative bioavailability in contaminated soils: Coupling mouse bioassay with UBM assay".Environment International 130(2019):104875.