On-line SERS detection of adenine in DNA based on the optofluidic in-fiber integrated GO/PDDA/Ag NPs | |
Gao, Danheng3; Yang, Xinghua3; Teng, Pingping3; Kong, Depeng4; Liu, Zhihai3; Yang, Jun3; Luo, Meng3; Li, Zhanao3; Wen, Xingyue3; Yuan, Libo3,5 | |
刊名 | SENSORS AND ACTUATORS B-CHEMICAL |
2021-04-01 | |
卷号 | 332 |
关键词 | In-fiber Raman senor Optofluidic microstructured optical fiber Adenine of DNA |
ISSN号 | 0925-4005 |
DOI | 10.1016/j.snb.2021.129517 |
产权排序 | 2 |
英文摘要 | In this paper, a novel type of in-fiber optofluidic Raman self-assembly graphene oxide (GO)/PDDA/Ag NPs SERS sensor for the adenine in DNA is proposed. The microstructured hollow fiber (MHF) has a channel and a suspended core in microscale, which allows the sample to flow into the fiber. Meanwhile, the GO/PDDA/Ag NPs SERS substrates are modified on the MHF core by chemical bond. When the sample is interacted with the evanescent field excited by the suspended core, the on-line SERS signals can be coupled back to the core and be detected. Here, we carry out on-line optofluidic detection on the adenine samples. The results show that the detection limit (LOD) of the samples of is about 1 x 10(-14) M. The unwound DNA solution extracted from biological blood is injected into the MHF. Under the action of the hydrogen bond between PDDA with adenine, the adenine base in DNA is successfully detected and the interference of guanine, cytosine and thymine is eliminated. Significantly, this work provides an integrated self-assembled GO/PDDA/Ag NPs SERS adenine sensor in an optofluidic fiber. This rapid, convenient and sensitive Raman detection sensor of adenine in DNA is expected to have more potential applications in HIV, genetics and other fields. |
语种 | 英语 |
出版者 | ELSEVIER SCIENCE SA |
WOS记录号 | WOS:000618771800006 |
内容类型 | 期刊论文 |
源URL | [http://ir.opt.ac.cn/handle/181661/94516] |
专题 | 西安光学精密机械研究所_信息光子学研究室 |
通讯作者 | Yang, Xinghua; Teng, Pingping |
作者单位 | 1.Univ South Wales, Fac Comp Engn & Sci, Wireless & Optoelect Res & Innovat Ctr, Pontypridd CF37 1DL, M Glam, Wales 2.Xian Modern Control Technol Res Inst, Xian 710065, Peoples R China 3.Harbin Engn Univ, Coll Sci, Key Lab In Fiber Integrated Opt, Minist Educ, Harbin 150001, Peoples R China 4.Chinese Acad Sci, Xian Inst Opt & Precis Mech, State Key Lab Transient Opt & Photon, Xian 710119, Peoples R China 5.Guilin Univ Elect Technol, Photon Res Ctr, Guilin 541004, Peoples R China |
推荐引用方式 GB/T 7714 | Gao, Danheng,Yang, Xinghua,Teng, Pingping,et al. On-line SERS detection of adenine in DNA based on the optofluidic in-fiber integrated GO/PDDA/Ag NPs[J]. SENSORS AND ACTUATORS B-CHEMICAL,2021,332. |
APA | Gao, Danheng.,Yang, Xinghua.,Teng, Pingping.,Kong, Depeng.,Liu, Zhihai.,...&Wang, Xiaozhang.(2021).On-line SERS detection of adenine in DNA based on the optofluidic in-fiber integrated GO/PDDA/Ag NPs.SENSORS AND ACTUATORS B-CHEMICAL,332. |
MLA | Gao, Danheng,et al."On-line SERS detection of adenine in DNA based on the optofluidic in-fiber integrated GO/PDDA/Ag NPs".SENSORS AND ACTUATORS B-CHEMICAL 332(2021). |
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