Matrix Metalloproteinase Expressions Play Important role in Prediction of Ovarian Cancer Outcome | |
Wang, Shujie1,2; Jia, Jia1,2; Liu, Dongyan1,2; Wang, Meng3; Wang, Zhen3; Li, Xueling1,2; Wang, Hongzhi1,2; Rui, Yong1; Liu, Zhirong1; Guo, Wei1,2 | |
刊名 | SCIENTIFIC REPORTS |
2019-08-12 | |
ISSN号 | 2045-2322 |
DOI | 10.1038/s41598-019-47871-5 |
英文摘要 | Ovarian cancer has a high death rate and is often not detected until late stages. While some studies found high expressions of MMPs correlated with cancer invasion, metastasis, and poor prognosis, however, several other studies indicated MMPs might inhibit cancer rather than promote cancer in certain situations. Thus, the role of different MMPs in different cancer types needs a systematic reevaluation. In this study, we used RNA-Seq and corresponding clinical data downloaded from TCGA and analyzed the correlations between MMP expressions and the clinicopathologic characteristics and outcome in ovarian serous cystadenocarcinoma (OSC) patients. Among the MMPs investigated, MMP-3 was significantly increased in high-grade and high-stage tumors compared with low-grade and low-stage ones. Using univariate analysis and multivariate Cox model, high expressions of MMP-19 and -20 were found to associate with poor overall survival independent of clinicopathologic characteristics. Moreover, using in vitro studies, we found ovarian cancer cell lines with higher MMP-19 and -20 protein expressing levels were associated with anti-cancer drugs resistance, while knockdown of MMP-19 or -20 increased ovarian cancer cell sensitivities to several clinical using chemotherapy agents. Finally, knockdown of MMP-19 or -20 also decreased the invasion abilities of several ovarian cancer cell lines. These in vitro studies provided potential mechanisms of high MMP-19 and -20 expressions in the poor prognosis of ovarian cancer. |
资助项目 | National Natural Science Foundation of China[81572948] ; National Natural Science Foundation of China[21772201] ; National Natural Science Foundation of China[Y7BY0E1501F] ; One Hundred Talents Projects of the Chinese Academy of Sciences |
WOS关键词 | PROGNOSTIC-SIGNIFICANCE ; MMP-9 ; CARCINOMA ; SURVIVAL ; INVASION ; OPINION ; TIMP-2 |
WOS研究方向 | Science & Technology - Other Topics |
语种 | 英语 |
出版者 | NATURE PUBLISHING GROUP |
WOS记录号 | WOS:000480385200070 |
资助机构 | National Natural Science Foundation of China ; One Hundred Talents Projects of the Chinese Academy of Sciences |
内容类型 | 期刊论文 |
源URL | [http://ir.hfcas.ac.cn:8080/handle/334002/73873] |
专题 | 健康与医学技术研究所 |
通讯作者 | Nie, Jinfu; Dai, Haiming |
作者单位 | 1.Chinese Acad Sci, Hefei Canc Hosp, Hefei, Anhui, Peoples R China 2.Chinese Acad Sci, Ctr Med Phys & Technol, Hefei Inst Phys Sci, Anhui Prov Key Lab Med Phys & Technol, Hefei, Anhui, Peoples R China 3.Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Hefei Inst Stem Cell & Regenerat Med, Hefei, Anhui, Peoples R China |
推荐引用方式 GB/T 7714 | Wang, Shujie,Jia, Jia,Liu, Dongyan,et al. Matrix Metalloproteinase Expressions Play Important role in Prediction of Ovarian Cancer Outcome[J]. SCIENTIFIC REPORTS,2019. |
APA | Wang, Shujie.,Jia, Jia.,Liu, Dongyan.,Wang, Meng.,Wang, Zhen.,...&Dai, Haiming.(2019).Matrix Metalloproteinase Expressions Play Important role in Prediction of Ovarian Cancer Outcome.SCIENTIFIC REPORTS. |
MLA | Wang, Shujie,et al."Matrix Metalloproteinase Expressions Play Important role in Prediction of Ovarian Cancer Outcome".SCIENTIFIC REPORTS (2019). |
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